Column_Selector_Documentation_v0.93参考中老师们.pdfVIP

Dionex Column Selector Demo Version 0.93 for Windows® Getting Started Guide  2001 - 2002 Dionex Corporation Introduction Welcome to the Dionex Column Selector, the simulation software for Ion Chromatographic retention modeling and optimization. Dionex Column Selector is a powerful application that uses previously acquired (embedded) retention data to simulate all possible chromatograms in a defined search area. Dionex Column Selector determines the optimal eluent composition using a choice of two resolution criteria, Minimum Resolution or Normalized Resolution Product. Dionex Column Selector is designed with the needs of a range of users in mind. It is intended for practical method development, educational and training purposes, refinement of existing methods and exploratory investigations including information gathering and experimental design overview. Dionex Column Selector uses the most advanced retention prediction models available today to achieve accurate prediction of chromatograms. Embedded data, which have been acquired using a correct experimental design, are used to solve these models. Dionex Column Selector uses these retention prediction algorithms to predict retention data across the entire search area. Dionex Column Selector ranks these virtual chromatograms according to two criteria, the Minimum Resolution or Normalized Resolution Product. A value of zero indicates that at least one peak pair is co-eluting. For the Minimum Resolution criterion, a value of 1.5 is generally regarded as baseline separation ( 0.2 % peak area overlap), although a value of 1.2 is often considered acceptable resolution for most applications ( 2 % peak area overlap). For the Normalized Resolution Product, a value of one indicates that all peaks are evenly resolved across the chromatogram. Detailed information about the Retention Models and Resolution Algorithms can be found in Appendix A. Dione