老年2型糖尿病与轻度认知功能障碍的关系研究.docVIP

·1537 · · 论 著 · 老年2型糖尿病与轻度认知功能障碍的关系研究 李敏，张丽，王敏哲 【摘要】 目的 探讨轻度认知功能障碍 (MCI) 的影响因素并分析可能影响2型糖尿病 (T2DM) 患者认知功 能的危险因素。方法 选取T2DM 患者140例和非T2DM 患者102例，将其分为MCI 组(126例)与认知功能正常组 (NC 组，116例)。对影响认知功能的因素进行单因素、多因素Logistic 回归分析。140例T2DM 患者中，合并MCI 者 94例，认知功能正常者46例，对T2DM 认知功能的影响因素进行Logistic 回归分析。结果 (1)患有糖尿病、收缩 压增高是MCI 的危险因素，而文化程度高是MCI 的保护因素。(2)血糖控制情况〔以糖化血红蛋白 (HbA?。) 表示〕、 微血管积分是T2DM 患者MCI 的危险因素，文化程度高是T2DM 患者MCI 的保护因素 (P0.05)。 结论 ( 1 ) 控 制 血糖和血压有利于改善老年人的认知功能。(2) T2DM 是影响MCI 发生、发展的重要危险因素。 【关键词】 糖尿病；认知障碍；危险因素 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2011)05-1537-03 Cl inical Research on the Relationship between Type 2 Diabetes and Mild Cognitive Impairment LI Min,ZHANG Li, WANG Min-zhe. Endocrinology Department, the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Chi- na 【Abstract] Objective To investigate influence factors of mild cognitive impairment and analysis risk factors of the dia- betic mild cognitive Impairment. Methods (1)140 cases of Type 2 Diabetics and 102 cases of nomal cases were divided into the MCI group and NC group. multiple factor logistic regression analysis were conducted to analysis the impact factors to affect the cognitive impairment.(2)140 cases of T2DM were divided into the MCI group and NC group. Single and multiple factor logis- tic regression analysis were conduet to analysis the impact factors to affect the diabetic cognitive impairment. Results (1) Type 2 Diabetics and Systolic blood pressure were the influence factors for MCI, and educational background was the protective factor of MCI.(2)Multivariate analysis Logistic demonstrated that controlling over the blood sugar(HbA,e)and microangiopa- thy were the influencing factors for MCI, educational background was the protective factor of MCI. Conclusion (1)Control- ling over the blood sugar and blood pressue are beneficial to improve the cognitive function of the aged people.(2)Type 2 Dia- betics is an important factor that influence occurr