女性2型糖尿病与睡眠相关行为的相关性研究.docVIP

· 2632 · · 论 著 · 女性2型糖尿病与睡眠相关行为的相关性研究 李志强，吴东妮，刘海艳，肖艳杰，卢智泉，孙晓晶 【摘要】 目的 研究女性2型糖尿病 (T2DM) 与睡眠相关行为(午睡情况、晚睡情况、打鼾情况、入睡情况、 夜间睡眠充足与否及睡眠质量)之间的关系。方法 采取以医院为基础的病例对照研究。病例为首次确诊的女性 T2DM 患者，对照者为同期住院并住同一医院的非T2DM 及相关代谢性疾病女性患者。病例与对照各192例，按1:1匹 配。采用国际匹兹堡睡眠质量指数量表 (PSQI) 和自行设计的一般状况调查表对两组研究对象进行调查问卷。采用t 检验及条件Logistic回归模型对睡眠质量及睡眠相关行为与女性T2DM 之间的关系进行分析。结果 病例组与对照组睡 眠质量 (PSQI 总分)比较，差异有统计学意义 (t=7.60,P0.01)。 多元条件Logistic 回归显示：睡眠相关行为—— 打鼾情况、睡眠质量、夜间睡眠情况及午睡情况与T2DM 发病存在关联〔0R 值分别为5.749、5.738、3.923、3.600; 95%CI 分别为(3.034,10.275)、(3.421,9.624)、(2.413,6.378)、(2.197,5.899)〕。结论 女性睡眠相关行为 与T2DM 发病密切相关，午睡缺乏、打鼾、夜间睡眠不足、睡眠质量差可能是女性T2DM 发病的危险因素，适当午睡 可能是女性T2DM 发病的保护性因素。 【关键词】 女性；睡眠；糖尿病，2型；危险因素；病例对照研究 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2012)08-2632-03 Analysis of Female Type 2 Diabetes Mellitus and Sleep - related Behaviors LI Zhi-qiang, WU Dong-ni,LIU Hai - yan, et al. Liaoning Medical University,Jinzhou 121001,China 【Abstract】 Objective To investigate the correlation between female type 2 diabetes mellitus(T2DM) and sleep-re- lated behaviors(nap, stay up, snoring, difficulty in sleeping, not enough sleep at night and sleep quality). Methods A hospital-based case- control study was conducted. The cases were females first diagnosed with T2DM, and the controls were females admitted to the same hospital in the same period without T2DM and metabolism diseases. The cases and controls were both 192 and matched by 1:1. International Pittsburgh Sleep Quality Index(PSQI) and self -designed general condition investi- gation questionnaire were used to survey all subjects. The correlation between sleep quality, sleep - related behaviors(nap, stay up, snoring, difficulty in sleeping, not enough sleep at night and sleep quality)and female T2DM was analyzed by t -test and conditional Logistic regression models. Results The sleep quality(total PSQI scores)between the case group and control group showed statistically significant difference(t=7.60,P0.01). Multiva