帕罗西汀联合心理干预对2型糖尿病伴发抑郁症的疗效.docVIP

维普资讯hp//www cqvpcom · 805 · · 论 著 · 帕罗西汀联合心理干预对2型糖尿病伴发抑郁症的疗效 孙全新，段武钢，陈克全，郭衍坤 【摘要】 目的 探讨帕罗西汀联合心理干预对伴发抑郁症的2型糖尿病患者的临床疗效及对患者血糖的影响。 方法 将64例伴发抑郁症的2型糖尿病患者随机分为研究组 I (常规治疗+帕罗西汀联合心理干预组，23例)、研究 组Ⅱ(常规治疗+心理干预组，21例)和对照组(常规治疗组，20例),均治疗8周。以汉密尔顿抑郁量表 (HAMD) 评定疗效，以副反应量表 (TESS) 评定不良反应，用糖化血红蛋白 (HbA;。) 水平监测血糖控制情况。 结果 治疗8周后，研究组I 患者HAMD 评分的改善明显优于研究组Ⅱ和对照组 (P0.01), 研究组Ⅱ患者 HAMD 评分 的改善明显好于对照组 (P0.05)。 治疗后研究组I 患 者HbA1。水平的改善明显好于研究组Ⅱ和对照组 (P0.05 或0.01),而研究组Ⅱ和对照组患者HbA;。水平间差别无显著性意义 (P0.05)。 治疗期间3组患者均未出现严重 不良反应。 结论 帕罗西汀联合心理干预能明显改善2型糖尿病患者伴发的抑郁症，且有利于患者血糖的控制。 【关键词】 糖尿病，2型；抑郁症；帕罗西汀；心理疗法 【中图分类号】 R587. 【文献标识码】 A 【文章编号】1007-9572(2006)10-0805-02 Ef fect of Paroxetine Associated with Psychological Intervention on Depression in Type 2 Diabetic Patients SUN Quan - xin,DUAN Wu -gang,CHEN Ke-quan,et al. The Second Hospital Affiliated to Xianning University,Xianning 437100,China 【Abstract] Objective To explore the clinical curative effect of paroxetine combined with psychological intervention on depressive disorder and blood glueose in type 2 diabetic patients. Methods 64 patients with type 2 diabetes and depressive dis- order were randomly assigned to study group I(routine therapy + paroxetine with psychological intervention, 23 cases),study groupⅡ(routine therapy +psychological intervention,21 cases)and control group(routine therapy,20 cases)for 8 weeks treatment, the clinical effect and side reaction were evaluated separately with HAMD and TESS before and after the treatment. HbAie levels were oblained to monitor glycemic control. Results After 8 weeks, improvement on HAMD scores was significant- ly grealer in study group I than that in study groupI or in control group(P0.01),and the scores of HAMD were significantly lower in study groupⅡ than those in control group(P0.05). After the treatment,the improvement on blood levels of HbAte was significantly greater in study group I than that in study group l or in control group(P 0.05～0.01),but there was no differen