妊娠期糖尿病患者血清同型半胱氨酸检测及临床意义.docVIP

hej16318@163.com 第34卷 2013年 第3期 5 月 中山大学学报(医学科学版) JOURNAL OF SUN YAT-SEN UNIVERSITY(MEDICAL SCIENCES) Vol.34 No.3 May. 2013 妊娠期糖尿病患者血清同型半胱氨酸检测及临床意义 李茂宇1,2,贺 晶1 · (1.浙江大学医学院附属妇产科医院产科，浙江杭州310006;2.浙江省湖州市妇幼保健院产科，浙江湖州313000) 摘 要：【目的】研究妊娠期糖尿病患者血清同型半胱氨酸(HCY) 水平及临床意义。【方法】以2012年5月至2012年 8月期间，湖州市妇幼保健院住院分娩的153例妊娠期糖尿病妇女为观察组，并按血糖控制程度分为 A1 组 和A2 组，同时选 取同期单胎孕晚期妇女90例为对照组，研究其血清同型半胱氨酸水平以及同型半胱氨酸和妊娠结局的相关性。【结果】结果 显示，A2 组血清 HCY 水平(11.98±4.05)较A1 组(8.88±2.63)及对照组(8.86±2.48)明显升高(P0.01)。 单因素方差分析 显示年龄、体质量、产次、孕周、血清 HCY、 空腹血糖水平等因素影响母婴不良结局的发生，logistic 回归分析提示孕周和血清 HCY 水平是影响妊娠结局发生的独立因素。【结论】血清 HCY 水平可能与妊娠期糖尿病的发展程度和妊娠结局密切相关， 对妊娠期糖尿病妇女监测血 HCY 比监测单次血糖可能更有助于判断不良结局的发生风险。 关键词： 同型半胱氨酸；妊娠期糖尿病；血糖 中图分类号：R714.256 文献标志码：A 文章编号： 1672-3554(2013)03-0461- 05 Determination of Plasma Homocysteine in Gestational Diabetes Mellitus and Its Clinical Significance LI Mao-yu2, HE Jing · (1.Department of Obstetrics, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; 2.Department of Obstetrics, Huzhou Maternity Child Care Hospital, Huzhou 313000,China) Abstract:【Objective 】 To investigate clinical significance of gestational diabetes mellitus (GDM) by detecting the level of homocysteine.【Methods 】A total of 153 cases of GDM gravida were selected as observation group in Huzhou Womens and Childrens Hospital from May 2012 to August 2012, and they were divided into group A1 and A2 according to the blood glucose level. 90 cases healthy pregnant women were selected as control group during the same period. Serum homocystein concentration was studied of all the cases,and the correlation between homocysteine and pregnancy outcomes was analyzed.【Results 】The serum HCY level in group A2 (11.98±4.05) was significantly higher than that in group A1(8.88±2.63)and control group(8.86±2.48)(P0.01). Univariate analysis showed that age, weight, parity, gestational age,HCY, fasting blood glucose affect the incidence of maternal and infant adverse outcomes of pregnancy. Logist