信号蛋白Smad1对2型糖尿病肾病诊断意义的初步研究.docVIP

·1127 · · 论 著 · 信号蛋白 Smad1 对2型糖尿病肾病诊断意义的初步研究 周淑红，李蒙，施秉银，崔波，吕宏军，徐利 【摘要】 目的 探讨信号蛋白Smad1 在2型糖尿病肾病诊断中的价值。方法 选择我院2型糖尿病患者50例， 根据24 h 尿微量白蛋白定量分为2组：糖尿病无肾病组27例和糖尿病肾病组23例；同期相匹配的健康体检者24例为 正常对照组，用酶联免疫吸附法 (ELISA) 测定所有受试者血和尿中Smad1 的水平。结果 血Smad1 在正常对照组为 41.4(32.8,66.7)ng/L, 糖尿病无肾病组为23.6(19.7,29.3) ng/L, 糖尿病肾病组为24.3(22.3,25.9) ng/L。 尿Smad1 在正常对照组32.7(29.1,36.7) ng/L, 糖尿病无肾病组24.3(17.0,32.1) ng/L, 糖尿病肾病组19.1 (13.8,23.6)ng/L。 血和尿Smad1 在糖尿病无肾病组和糖尿病肾病组均低于正常对照组，差异有统计学意义 (P 0.05),但在糖尿病无肾病组和糖尿病肾病组间差异无统计学意义 (P0.05)。 多元线性回归分析显示，血和尿Smadl 与肾功能相关指标均无相关性。 结论 信号蛋白Smad1 可能不是2型糖尿病肾病诊断中一个有价值的指标。 【关键词】 Smadl; 糖尿病，2型；糖尿病肾病 【中图分类号】 R587.24 【文献标识码】 A 【文章编号】1007-9572(2012)04-1127-03 Evaluation of Signal Protein Smad1 in Diagnosis of Diabetic Nephropathy in Type 2 Diabetic Patients ZHOU Shu-hong, LI Meng,SHI Bing-yin, et al. Department of Endocrinology, the First Hospital Affliated to Xian Jiaotong University,Xian 710061,China 【Abstract] Objective To investigate the evaluation of Smadl in diagnosis of type 2 diabetic nephropathy. Methods Fifty type 2 diabetic patients in our hospital were divided into two groups by the content of 24 -h urinary microalbumin: normal microalbumin(NC) group(n=27)and mass microalbumin(DN) group(n=23). Meanwhile 24 health people were chosen as the normal control group. Serum and urinary Smadl were determined with ELISA. Results The serum Smadl content was 41.4 (32.8,66.7)ng/L in the NC,23.6(19.7,29.3)ng/L in DM and 24.3(22.3,25.9)ng/L in DN. The urinary Smad1 content was 32.7(29. 1,36.7)ng/L in NC,24.3(17.0,32. 1)ng/L in DM and 19. 1(13.8,23.6)ng/L in DN. Both of Serum and urinary Smad1 content in diabetic groups were lower than those in NC(P0.05). There was no statistical signifi- cant difference between DM and DN(P0.05). There was no correlation between the levels of Smad1 and renal - related indi- cators in diabetic patients by multi -linear regression model analysis. Conclusion The Smadl could not be a valuable