妊娠期糖尿病高危因素与产后早发糖代谢异常的关系.docVIP

第32卷 2011年第6期 第32卷 2011年 第6期 11月 Vol.32 No.6 Nov. 2011 JOURNAL OF SUN YAT-SEN UNIVERSITY(MEDICAL SCIENCES) 妊娠期糖尿病高危因素与产后早发糖代谢异常的关系 莫 小 庆 , 王 子 莲 2 , 曹 筱 佩 1 , 肖 海 鹏 , 李 延 兵 1 (中山大学附属第一医院1.内分泌科，2.妇产科，广东广州510080) 摘 要：【目的】探讨妊娠期糖尿病(GDM) 传统高危因素与妊娠结局及产后早发糖代谢异常的关系。【方法】3017名孕 妇以高危因素或50g 葡萄糖筛查试验进行GDM 筛查，阳性者行75g 口服葡萄糖耐量试验(OGTT) 确诊 GDM,GDM 孕妇分 为高危因素组(G1 组 ，n=143) 与非高危因素组(G2 组，n=175), 并于产后6~8周及产后6～12月复查OGTT。 【结果】3017 名孕妇中318例确诊GDM, 存在高因危素的孕妇GDM 患病率明显高于无高危因素的孕妇(41.81% VS 6.54%,P0.01),且 分娩期并发症发生率、早产率以及胎儿体质量更高，产后6～12个月持续糖代谢异常率亦明显升高。 Logistic 回归分析显示 糖尿病家族史、尿糖阳性与产后糖代谢异常相关。【结论】存在GDM 高危因素的孕妇GDM 患病率明显升高，产后持续糖代 谢异常的概率亦显著升高，其中尿糖阳性与糖尿病家族史有较高的相关性。 关键词：妊娠期糖尿病；高危因素；产后早发糖代谢异常；妊娠结局 中图分类号：R714.256;R587.1 文献标志码：A 文章编号：1672-3554(2011)06-0791-04 Relationship between Risk Factors of GDM and Postpartum Early Abnormal Glucose Regulation MO Xiao-qing, WANG Zi-lian2, CAO Xiao-pei, XIAO Hai-peng, LI Yan-bing (1.Department of Endocrinology, 2. Department of Obstetrics and Gynecology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080,China) Abstract:【Objective 】To investigate the relationship between traditional risk factors of gestational diabetes mellitus(GDM)and pregnancy outeome as well as postpartum early abnormal glucose regulation.【Methods 】 Risk factors or 50 g oral glucose tolerance test (OGTT) were used to scan GDM in 3017 pregnant women, the 75 g OGTT were performed to confirm the diagnosis of GDM in those with positive results. GDM women were divided into two groups; women with risk factors (n = 143)and without risk factors (n = 175). All GDM women were recruited to take 75 g OGTT at 6-8 weeks and 6- 12 months after delivery.【Results 】 Total 318 GDM were confirmed in those 3017 pregnant women. The prevalence of GDM in women with risk factors were higher than those without risk factors (41.81% vs 6.54%,P0.01). Additionally, compare to those without risk factors, women with risk factors has higher pr