高龄2型糖尿病患者血清超敏C反应蛋白及细胞因子检测的临床意义.docVIP

· 492 · 医学研究生学报2010年5月第23卷第5期JMed Postgra,Vol. 23,No. 5,May,2010 论 著 (临床研究) 高龄2型糖尿病患者血清超敏 C 反应蛋白及细胞因子 检测的临床意义 朱小蔚，张兴虎，万文辉，刘永华，钱晓明 [摘要] 目 的 近来研究显示，炎症因子在2型糖尿病(type 2 diabetes mellitus,T2DM) 发病机制中起媒介作 用。文中主要探讨高龄(≥80岁)T2DM 患者血清超敏 C 反应蛋白(high sensitive C-reactive protein,HsCRP)及细胞 因子水平变化。 方法 选取高龄糖尿病患者45例(糖尿病组)和高龄健康人36例(对照组)分别检测血清 HsCRP、 白细胞介素(interleukin,IL)-2、IL-6 及肿瘤坏死因子- α(tumor necrosis factor-a,TNF- α)水平。经彩色多普 勒检查2组患者颈动脉内膜- 中膜增厚(intima-media thickness,IMT)、斑块形成来评判动脉粥样硬化(atherosclerosis, AS) 的程度。 结果 高龄2型糖尿病组的血清 HsCRP 、IL-6 、TNF-α 水平明显高于对照组(P0.05), 而前组的 IL-2 水平明显低于后组(P0.05)。 与对照组相比，糖尿病组 AS 的程度更严重 (P0.05)。 结 论 血 清 HsCRP、IL-6、TNF- α水平的升高以及 IL-2 水平的降低可能参与高龄2型糖尿病的发病机理，并与糖尿病患者 AS 的 发生及其严重程度相关。 [关键词] 高龄；2型糖尿病；细胞因子；超敏C 反应蛋白；动脉粥样硬化 [中图分类号] R587.1 [文献标志码] A [文章编号] 1008-8199(2010)05-0492-03 Clinical significance of determination of serum high sensitive C-reactive protein and cytokine levels in the very elderly with type 2 diabetes mellitus ZHU Xiao-wei, ZHANG Xing-hu, WAN Wen-hui,LIU Yong-hua, QIAN Xiao-ming (Department of Geriatrics, Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002, Jiangsu,China) [ Abstract ] Objective Recent studies have suggested that inflammatory factors were the intermediate in the pathogenesy of type 2 diabetes mellitus(T2DM). Our research is to investigate the changes of serum hypersensitive C-re- active protein(HsCRP)and cytokine levels in the very elderly with T2MD. Methods The serum levels of HsCRP, IL-2,IL-6,TNF-awere observed in 45 very elderly patients with T2 MD, and compared with those in 36 very elderly con- trols. Carotid artery intima-media thickness(JMT)and atherosclerotic plaque were also examined in order to evaluate the degree of atherosclerosis(AS). Results The serum levels of HsCRP, IL-6 and