活性益生菌治疗过敏性鼻炎的临床观察及免疫调节作用分析.pdfVIP

·五官医学·中国现代医生2017年2月第55卷第5期

活性益生菌治疗过敏性鼻炎的临床观察及

免疫调节作用分析

金日群廖志莹王英斌刘芳

赣南医学院第一附属医院耳鼻咽喉头颈外科，江西赣州341000

摘【要】目的探讨活性益生菌治疗过敏性鼻炎的临床效果及对免疫指标的影响。方法按照人院顺序抽签后将

120例持续性过敏性鼻炎随机分为益生菌组和对照组，每组60例，对照组患者予常规抗组胺治疗，益生菌组在此

基础上加用益生菌治疗，比较疗程结束时两组的临床疗效、两组患者治疗前后血清各项免疫指标水平及症状体

征明显改善时间。结果益生菌组患者治疗后的总有效率显著高于对照组，差异有统计学意义(P0．05)；益生菌

组患者治疗后血清TIgE、slgE、IL一4水平均显著低于对照组，差异有统计学意义(PO．05)；益生菌组患者阵发性

喷嚏、清水样涕、鼻痒、鼻塞明显改善时间均显著短于对照组，差异有统计学意义(PO．05)。结论活性益生菌治

疗过敏性鼻炎临床效果显著，可有效改善患者的免疫指标，缩短康复时间，应用价值高。

关【键词】过敏性鼻炎；活性益生菌；抗组胺；免疫指标

中【图分类号】R76文【献标识码】B文【章编号】1673—9701(2017)05—0066—03

Clinicalobservationofactiveprobioticsinthetreatmentofallergicrhini-

tisandanalysisofitseffectonimmunoregulation

JINRiqunL1A0ZhiyingWANGYingbinLIUFang

DepartmentofE．N．TandHeadandNeckSurgery，theFirstAffiliatedHospitalofGannanMedicalUniversity，Ganzhou

341000，China

[Abstract]0bjectiveToexploretheclinicaleffectofactiveprobioticsinthetreatmentofallergicrhinitisanditseffect

0nimmuneindices．Methods120patientswithpersistentallergicrhinitiswererandomlydividedintoprobiotiesgroup

andcontrolgroupaccordingtotheorderofadmission，60casesineachgroup．Patientsinthecontrolgroupweregiven

conventionalantihistaminetherapy，andpatientsintheprobioticsgroupwerefurthergivenprobioticsonthebasisofthe

controlgroup．Attheendofthecourseoftreatment，theclinicalefficacy。levelsofserumimmuneindicatorsbeforeand

aftertreatmentandsignificantimprovementtimeofsymptomsandsignswerecomparedbetweenthetwogroups．Results

Thetotaleffectiverateintheprobioticsrgoupwassignificantlyhigherthanthatinthecontrolgroup，andthedifference

wasstatisticallysignificant(PO．05)；thelevelsofserumTIgE，sIgEandIL-4intheprobioticsgroupweresignificantly

lowerthanthoseinthecontrolgroup，andthedifferenceswerestatisticallysigni