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BRL-32872

Cat.No.:HY-19117

CASNo.:113241-47-7

分⼦式:C₂₉H₃₆ClN₃O₇

分⼦量:574.07

作⽤靶点:PotassiumChannel

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BRL-32872是⼀种强效的humanether-a-go-go-relatedgene(hERG)钾离⼦通道阻滞剂(在分离的⼼肌细胞中

，IC50值为241nM；在HEK293细胞中为19.8nM)。BRL-32872有望⽤于⼼脏⼼律失常(如⼼房/⼼室节律)

的研究。

REFERENCES

[1].ThomasD,etal.High-affinityblockadeofhumanether-a-go-go-relatedgenehumancardiacpotassiumchannelsbythenovel

antiarrhythmicdrugBRL-32872.JPharmacolExpTher.2001May;297(2):753-61.

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