MDL-73811-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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MDL73811

Cat.No.:HY-112252

CASNo.:123642-27-3

分⼦式:C₁₅H₂₃N₇O₃

分⼦量:349.39

作⽤靶点:Parasite

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MDL73811isapotentAdoMetDCinhibitorandanti-trypanosomalcompound.MDL73811hascurative

efficacyinahemolymphaticmodelofHAT[1].

IC50TargetTrypanosoma

REFERENCES

[1].BrockwayAJ,etal.Synthesisandevaluationofanalogsof5-(((Z)-4-amino-2-butenyl)methylamino)-5-deoxyadenosine(MDL73811,or

AbeAdo)-AninhibitorofS-adenosylmethioninedecarboxylasewithantitrypanosomalactivity.BioorgMedChem.2017Oct15;25(20):5433-

5440.

[2].BrockwayAJ,etal.ImprovedSynthesisofMDL73811-aPotentAdoMetDCInhibitorandAnti-TrypanosomalCompound.Synthesis

(Stuttg).2016Jul;48(13):2065-2068.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.