用于离子通道Markov模型参数优化的进化策略方法研究.docVIP

  用于离子通道 Markov 模型参数优化的进化 策略方法研究# 肖峰1，丁明跃1，丁久平2，尉迟明1** 5 10 15 20 25 30 35 40 （1. 图像处理与智能控制教育部重点实验室，生命科学与技术学院，华中科技大学，武汉， 430074； 2. 分子生物物理教育部重点实验室，生命科学与技术学院，华中科技大学，武汉， 430074） 摘要：离子通道是一切生命活动的电生理基础。Markov 模型在离子通道的电生理特性的分 析和研究中是一个十分有用的工具。Markov 模型一般都包含一组参数，由于参数的数量较 多，通常很难确定。基于此，我们提出一个以细胞电生理知识为基础用于离子通道 Markov 建模的进化策略（ES）方法。首先，从大量的电压—电流的数据选取若干具有代表性的曲 线组合用于 ES 方法建模。然后，从选定的曲线选出若干能够反映曲线变化的特征点用以构 建 ES 方法的适应度函数。最后，设计具体的 ES 遗传算子并进行模型参数优化。文中用到 的所有数据均采集自实际细胞。得到的结果可以说明提出的方法的潜力。 关键词：建模与优化；进化算法；离子通道；Markov 模型 中图分类号：TP391.9 Evolutionary Strategy for Ion Channel Markov Model Parameter Optimization XIAO Feng1, Dingmingyue1, Ding Jiuping2, YUCHI Ming1 (1. Key Laboratory of Image Processing and Intelligent Control of the Ministry of Education, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2. Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, , College of Life Science and Technology, Wuhan, 430074) Abstract: Ion channel is commonly recognized to be the electrophysiological basic of the life body. Markov model is a useful tool in ion channel electrophysiological activities research. However, the models always contain a group of parameters, which is hard to determine. In this study, a cell electrophysiological knowledge based Evolutionary Strategy (ES) method is proposed. Firstly, several voltage-current curves were selected from a large number of voltage-current data as the training curves of the ES. Then, feature information was exacted from the selected curves. Finally, the genetic operators of ES were designed to optimize the model parameters. All the data used in this work came from the real experiments. The results show the potential of this proposed method. Key words: Modeling and Optimization; Evolitionary Algorithm; Ion Channel; Markov Model 0 引言 进化算法（Evolutionary Algorithm，EA）[1]是一类基于自然进化和遗传的概率方法。它 从一个初始种群开始，种群中包含的每一个个体都代表着问题的一个可能解决方案。个体通 过“遗传算子”进行进化得