汉族人群中HLA-DRB1共同表位相关的DR-DQ单倍型与CCP阳性及CCP阴性类风湿关节炎相关性研究.docVIP

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汉族人群中HLA-DRB1共同表位相关的DR-DQ单倍型与CCP阳性及CCP阴性类风湿关节炎相关性研究.doc

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The HLA–DRB1 Shared Epitope (SE)-associated DR-DQ Haplotypes is Predominantly Associated with Both Anti-Cyclic Citrullinated Peptides (CCPs) 5 10 15 20 25 30 35 40 45 antibodies–Positive and –Negative Rheumatoid Arthritis in Han Population# Xu Liu1, Jianping Guo1, Yuan Jia1, Yi Zhao2, Xia Liu3, Xiaolan Lu1, Feng Cheng4, Xiaoxia Li2, Yi Zheng5, Cibo Huang6, Yongjing Cheng6, Tian Wang7, Zhanguo Li1** (1. Department of Rheumatology and Immunology, Peking University Peoples Hospital, Beijing 100044; 2. Department of Rheumatology, Xuanwu Hospital Capital Medical University, Beijing 100053; 3. Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029; 4. Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081; 5. Department of Rheumatology, Chao-yang Hospital, Beijing 100020; 6. Department of Rheumatology, Beijing Hospital of the Ministry of Health, Beijing 100730; 7. Department of Internal Medicine, Beijing Anzhen Hospital Capital Medical University, Beijing 100029) Abstract: Introduction: The association between Human Leukocyte Antigen (HLA) class II alleles and rheumatoid arthritis (RA) has been extensively studied in multiple ethnic groups, but few have been reported in Chinese Han population. In this work, we investigated the association of HLA-DRB1, DQA1, DQB1, and the DRB1- DQA1-DQB1 (DR-DQ) haplotypes with RA susceptibility and with RA-specific antibodies against cyclic citrullinated peptides (anti-CCP) in Han population. Methods: High-resolution HLA-DRB1, DQA1 and DQB1 genotyping were performed in 281 RA patients and 202 healthy controls. The associations between DRB1, DQA1 and DQB1 alleles or haplotypes and RA susceptibility were evaluated. The presence of anti-CCP antibodies was analyzed in carriers of the different DR–DQ haplotypes.Results: The HLA-DRB1 shared epitope (SE)-encoding alleles *0101, *0405 and *0410 were highly susceptible to RA in Han population. In which, *0405 displayed the most sig