急性心肌梗死患者外周血GDF15水平表达上调.pdfVIP

572 Journal of Medical Science in Central South China,Nov.2012,Vol.40,No.6 文章编号:2095-1116(2012)06-0572-03 ·临床医学· 急性心肌梗死患者外周血 GDF15水平表达上调 1 1 1 1 1 1 1 2 杨摇 军 ,谭摇 芳 ,王苏燕 ,江振涛 ,邓摇 彪 ,丁赛良 ,张摇 勇 ,褚摇 春 (1.南华大学附属第一医院心内科,湖南衡阳421001;2.南华大学附属第二医院药剂科) 摘摇 要:摇 目的摇 探讨外周血血清生长分化因子15(GDF15)在稳定型心绞痛、急性心肌梗死及非冠心病人群 中的表达差异,评估血清GDF15 浓度在冠心病危险分层中的价值。 摇 方法摇 选取142例行冠状动脉造影术的住院 患者作为研究对象,其中急性心肌梗死(AMI)组患者61例,稳定型心绞痛(SAP)组患者41例,40例冠脉造影正常 者为对照组,分别测定其外周血血清GDF15 水平。 摇 结果摇 AMI组GDF15 水平显著高于对照组(P 0.05),亦显 著高于SAP组(P0.05)。 SAP组与对照组两组间GDF15 水平无统计学差异(P 0.05)。 摇 结论摇 急性心肌梗 死患者血清GDF15 水平明显升高,可能与患者的斑块不稳定性和心肌损伤密切相关,可作为预测和早期诊断急性 冠状动脉综合症的的参考指标。 关键词:摇 生长分化因子15;摇 急性心肌梗死;摇 稳定型心绞痛;摇 冠心病 中图分类号:R542郾22摇 摇 摇 文献标识码:A CorrelationAmong Serums GDF15Level andAcute Myocardial infarction YANGJun,TAN Fang,WANG Suyan,et al (Department of Cardiology,the FirstAffiliated Hospital,University of South China, Hengyang,Hunan421001,China) Abstract:摇 Objective摇 To observe serums GDF15 level and itsrelevance in different typesof coronary heart disease (CHD) in patients.摇 Methods摇 The present study was involved in 142 cases of patientswith CHD,including61cases of acute myocardial infarction (AMI),41of stableanginapector (SAP)and29 caseswithnocardiovasculardiseaseevidence served as control group.The levels of serums GDF15 were measured with enzyme linked immunosorbent assay and com鄄 pared.摇 Results摇 The levels of GDF15 in AMI was significantly higher than that in SAP group and control group ( P 0郾05).Group SAP compared with control group had no significant difference (P 0.05).摇 Conclusion摇 The serum GDF15 of acute myocardial inf