尼莫地平联合尼麦角林对缺血性脑卒中后认知功能的影响.pdfVIP

中南医学科学杂志2012年3 月第40卷第2期 185 文章编号:2095-1116(2012)02-0185-03 ·临床医学· 尼莫地平联合尼麦角林对缺血性脑卒中后认知功能的影响 刘淑云,张摇 平,蒋福生,曹摇 琳,张新华 (南华大学附属南华医院神经内科,湖南衡阳421002) 摘摇 要:摇 目的摇 探讨尼莫地平联合尼麦角林对缺血性脑卒中患者早期认知功能损害的干预效果。 摇 方法摇 回顾性分析116例缺血性脑卒中住院患者临床资料(常规治疗组57例,联合用药组59例)。 常规治疗组采取常规 缺血性脑卒中治疗方案,联合用药组在常规治疗组基础上加用尼莫地平以及尼麦角林。 两组均采用蒙特利尔认知 评估量表(北京版)在入院1周内及6 个月后分别进行临床评估。 摇 结果摇 6 个月后量表评分常规治疗组远低于联 合用药组(21.24依4.21比25.62依3.29,P 0.05)。 常规治疗组6 个月后评分低于入院时评分(21.24 依4.21 比 25.09依4.64,P0.05)。 摇 结论摇 缺血性脑卒中后认知功能损害发生率高。 尼麦角林联合尼莫地平早期干预能 明显延缓缺血性脑卒中后认知功能损害的进展。 关键词:摇 缺血性脑卒中;摇 认知功能;摇 尼莫地平;摇 尼麦角林 中图分类号:R743.3摇 摇 摇 文献标识码:A Nimodipine Combined With Nicergoline Treatment Ischemic Stroke Patinents With Vascular Cognitive Impairment LIU Shuyun,ZHANG Ping,JIANG Fusheng,et al (Department of Neurology,NanhuaAffiliated Hospital,University of South China, Hengyang,Hunan421001,China) Abstract:摇 Objective摇 To study the therapeutic effect of nimodipine combined with nicergoline treatment Ischemic strokepatinentswithvascular cognitive impairment.摇 Methods摇 Clinical data,116 subjectswererandomly divided into con鄄 ventional combinedtreatment group(57 patients) and combined treatment group of(59 patients),the conventional combined treatment group received conventional therapy,the combined treatment group received nimodipine and nicergoline.Montreal Cotive Assessment(MoCA) assessed in hospital and after6 months.摇 Results摇 The conventional combined treatment group MoCA scoreswerelowerthanthecombinedtreatmentgroupafter6month(21.24依4.21vs25.62依3.29,P0.05);thecon鄄 ventional combinedtreatment group MoCA scores after6 monthwere lower than before admission(2