关联分析在作物种质资源分子评价中的应用.pdfVIP

植物遗传资源学报 2007 , 8 ( 3) : 366～372 Journal of P lan t Genetic R e source s 关联分析在作物种质资源分子评价中的应用 王荣焕 ,王天宇 ,黎 　裕 (中国农业科学院作物科学研究所 ,北京　100081) 　　摘要 :发掘优异基因资源是作物种质资源分子评价的重要部分 ,对作物育种尤其是分子育种具有非常重要的实践意义 。 ( ) 基于连锁不平衡 LD 的关联分析是基因发掘也是等位基因发掘的有效途径 。本文系统介绍了关联分析的基本理论 、策略、特 ( ) 点及应用现状 ,并探讨了其在作物种质资源新 等位 基因发掘中的发展趋势及展望 。可以预见 ,与传统 Q TL 作图及功能基因 组学相整合的关联分析必将大大加快我国作物种质资源的研究进程 ,实现我国种质资源优势向基因资源优势的转变 。 关键词 :作物种质资源 ;连锁不平衡 ;关联分析 ;基因发掘 ;等位基因发掘 Applica tion of A ssoc ia tion Ana ly sis in M olecular Eva lua tion of Crop Germpla sm Resources WAN G Ronghuan , WAN G Tianyu , L I Yu ( Ins titu te of C rop S cience, Ch inese A cadem y of A g ricu ltu ra l S ciences, B eij ing 100081) 　　A b stract: Gene discovery and allele m in ing are importan t in mo lecu lar evaluation of crop germp la sm re sou rce s and are of great p ractical sign ificance in crop b reeding, e sp ecially in mo lecu lar b reeding. L inkage disequ ilib rium (LD ) ba sed a ssociation analysis is an effective app roach to find new gene s and favorab le allele s. In th is p ap er com p rehen sively ba sic theorie s, strategie s, characteristic s and cu rren t succe ssfu l app lication s of a ssociation analysis in crop s were reviewed. The trend s and p ro sp ects of a ssociation analysis were also p ropo sed. It is concluded that w ith the in tegration of trad itional Q TL m app ing and functional genom ic s, a ssociation analysisw ill certain ly accelerate the mo lecu lar evaluation of crop germp la sm re sou rce s. Key words:Crop germp la sm re sou rce s; LD ; A ssociation analysis; Gene d iscovery; A llele m in ing (