CYP2E1遗传型和饮酒习惯对广西肝癌易感性的影响_叶新平.pdfVIP

2008 Aug; 25(4) JOU NAL OF GUANGXI MEDICAL UNIVE SITY # 493 # CYP2E1 * 1 v ( 530021) : P450 2E1( CYP2E1) ( ) :300 292 ,PC - FLP CYP2E1 : CYP2E1 321 3%321 9% ( P 01 05) \3 () CYP2E1 3 () 11 299 11 803: CYP2E1 ; CYP2E1 CYP2E1 , P4502E1;; ; : 735 : A : 1005-930X( 2008)04-0493-03 THE EFFECT OF INTERACTION BETWEEN ALCOHOL DRINKING AND POLYMOR- PHISMS OF CYTOCHROME P450 2E1 ON THE SUSCEPTIBILITY OF HEPATOCELLULAR CARCINOMA IN GUANGXI REGION Ye Xinping, Peng Tao, Liu Tangwei, et al. ( Department of H epatobiliary Surgery , the First Affiliated Hospital of Guangxi Medical University, Nanning 530021 China) Abstract Object ve: T o study the relationship between CYP2E1 gene polymorphism and the susceptibility of hepatocellular carcinoma( HCC) . Methods: 300 cases of HCC and 292 controls were genotyped for the CYP2E1 polymorphisms by using polymerase chain reaction-restriction fragment length polymorphism (PC - FLP) . Result: T he frequencies of CYP2E1 variant genotypes in the cases and controls were 32. 3% and 32. 9%, respectively. There was no significant difference of CYP2E1 genotypes distribution between the cases and controls ( P 0.05) . T herisk for liver cancer was 1. 299 times and 1.803 times higher in al- coholics ( \3 times drinking per week) with CYP2E1c1 and CYP2E1c2 genotype than that in the cases car- rying CYP2E1c1 genotypewhile drinking less than 3 times per week ( P = 0.286 and 0.051) , respectively. Conclus on: CYP2E1 genotypes alone render no significant risk for HCC, while frequent alcoholic Con- sumption together with CYP2E1 variant genotypes may be associated with risk of hepatocarcinogenesis, su