尼可地尔对冠脉慢血流患者肱动脉血流介导的内皮依赖性血管舒张功能影响.docVIP

尼可地尔对冠脉慢血流患者肱动脉血流介导的内皮依赖性血管舒张功能影响 　　[摘要] 目的 探讨尼可地尔对冠状动脉慢血流（CSF）患者肱动脉血流介导的内皮依赖性血管舒张功能（FMD）影响。方法 经冠脉造影诊断为CSF患者120例，根据治疗方法分为对照组（n=60）与尼可地尔组（n=60）。对照组给予常规治疗，尼可地尔组给予常规治疗加尼可地尔治疗。于治疗前、治疗后3个月分别检测FMD、APN、hsCRP的水平。 结果 尼可地尔组患者的FMD较治疗前明显改善（P0.05）。 结论 尼可地尔能显著增加CSF患者FMD，改善内皮功能。 　　[关键词] 冠脉慢血流；尼可地尔；内皮依赖性血管舒张功能 　　[中图分类号] R543.3 [文献标识码] A [文章编号] 2095-0616（2013）13-12-02 　　Effects of nicorandil on endothelial-dependent flow-mediated vasodilation of the brachial artery in patients with coronary slow flow 　　WANG Tao1 LI Yuan2 XIAO Wenliang1 JIANG Zhian1 ZHANG Xiaoguang1 YIN Hongshan1 ZHAO Shujian1 ZHOU Chunxia1 ZHANG Song3 　　1.Department of Cardiology，Third Hospital of Heibei Medical University，Hebei 050051，China； 2.Department of Medicine，Forth Hospital of Shijiazhuang，Shijiazhuang 050051，China；3.Department of Clinical Laboratory，Third Hospital of Heibei Medical University， Shijiazhuang 050051，China 　　[Abstract] Objective To investigate the effect of nicorandil on endothelial-dependent flow-mediated vasodilation（FMD） of the brachial artery in patients with coronary slow flow（CSF）. Methods 120 patients with CSF were enrolled and randomized divided into control group（n=60）and nicorandil group（n=60）. Control group patients were administrated of conventional treatment，nicorandil group were administrated of nicorandil on the basis of conventional treatment. The levels of FMD，APN，hsCRP were measured before and three months after treatmeat. Results Compared with before treatment，FMD improved in nicorandil groups after treatment（P0.05），APN level increased（P0.05） whereas hs-CRP level decreased（P0.05）；changes of FMD was positively correlated with changes of APN，and was negativly correlated with changes of hs-CRP. FMD，APN and hs-CRP in control group had no significantly changes after 3 months treatment. Conclusion Nicorandil can improve the FMD of the brachial artery in patients with CSF. 　　[Key words] Coronary slow flow；Nicorandil；FMD 　　冠状动脉慢血流（CSF）是指排除冠状动脉痉挛、血栓、冠状动脉扩张等因素，冠脉造影（CAG）没有发现明显病