Prognostic Significance of Positive Circumferential Resection Margin in Esophageal Cancer A Systematic Review and Meta-Analysis》.pdf

G E N E R A L T H O R Prognostic Significance of Positive Circumferential A C I C Resection Margin in Esophageal Cancer: A Systematic Review and Meta-Analysis Jie Wu, MD, Qi-Xun Chen, MD, Li-song Teng, MD, PhD, and Mark J. Krasna, MD Department of Surgical Oncology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, China; and Meridian Cancer Care, Jersey Shore University Medical Center, Neptune, New Jersey Background. To assess the prognostic significance of p 0.001) according to the RCP and CAP criteria, respec- positive circumferential resection margin on overall sur- tively. Positive circumferential resection margin was asso- vival in patients with esophageal cancer, a systematic ciated with worse survival in patients with T3 stage disease review and meta-analysis was performed. according to the RCP (HR, 1.381; 95% CI, 1.028–1.584; p [ Methods. Studies were identified from PubMed, 0.001) and CAP (HR, 2.457; 95% CI, 1.902–3.175; p 0.001) EMBASE, and Web of Science. Survival data were criteria, respectively. Positive circumferential resection extracted from eligible studies to compare overall sur- margin was associated with worse survival in patients vival in patients with a positive circumferential resection receiving neoadjuvant therapy according to the RCP (HR, margin with patients having a negative circumferential 1.676; 95% CI, 1.023–2.744; p [ 0.040) and CAP (HR, 1.847; resection margin according to the Royal College of Pa- 95% CI, 1.226–2.78; p [ 0.003) criteria, respectively.