Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma》.pdf

Human Pathology (2014) 45, 2154–2161 /locate/humpath Original contribution Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma☆ Jun-qing Zhang MD a,1, Qing-he Yao MD, PhD b,1, Yong-qin Kuang MD c,1, c c c Yuan Ma MD, PhD , Li-bin Yang MD, PhD , Hai-dong Huang MD, PhD , c c c c Jing-ming Cheng MD, PhD , Tao Yang MD, PhD , En-yu Liu MD, PhD , Liang Liang MD , Ke-xia Fan MDc, Kai Zhao MD c, Xun Xia MD, PhD c,⁎, Jian-wen Gu MD, PhD c,⁎ aDepartment of Oncology, the 264th Hospital of PLA, Taiyuan, 030001, China bDepartment of Neurosurgery, Baoji Central Hospital, Baoji, 721008, China cDepartment of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China Received 29 October 2013; revised 3 January 2014; accepted 8 January 2014 Keywords: Summary Our aim was to investigate the expression of micro-RNA-200b (miR-200b) and cAMP- Astrocytoma; responsive element-binding protein 1 (CREB-1) in astrocytoma and its efficacy for predicting outcome. CREB-1; Both miR-200b and CREB-1 messenger RNA expression was measured in 122 astrocytomas and 30 Micro-RNA-200b; nonneoplastic brain specimens by quantitative real-time polymerase chain reaction. Expression of miR- Tumor progression; 200b was significantly lower