Prognostic value of PD-1 and TIM-3 on CD3+ T cells from diffuse large B-cell lymphoma》.pdf

Biomedicine Pharmacotherapy 75 (2015) 83–87 Available online at ScienceDirect Original article Prognostic value of PD-1 and TIM-3 on CD3+ T cells from diffuse large B-cell lymphoma a,b a,b a a a a Li Zhang , Hui Du , Tai-wu Xiao , Ji-zhu Liu , Guo-zhen Liu , Jing-xia Wang , a,b,** c,* Guang-yao Li , Le-xin Wang a Medicine school of Shandong University, Jinan, Shandong 250012, PR China b Division of Hematology, Liaocheng People ’s Hospital, Liaocheng, Shandong 252000, PR China c School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales 2650, Australia A R T I C L E I N F O A B S T R A C T Article history: Objective: To investigate the expression of PD-1 and TIM-3 in CD3+ T cells in patients with diffuse large B- Received 20 August 2015 cell lymphoma (DLBCL). Accepted 30 August 2015 Methods: A retrospective analysis was conducted on data from 46 patients with newly diagnosed DLBCL and 30 healthy people. Flow cytometry was used to detect the expression of PD-1 and TIM-3 before and Keywords: after chemotherapy. PD-1 Results: Compared to healthy control, the expression of PD-1 and TIM-3 in patients with DLBCL was TIM-3 increased in CD3+ T cells. There is no significant change of PD-1 and TIM-3 in pati