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Prostate cancer The main risk and protective factors – Epigenetic modifications》.pdf
Disponible en ligne sur
ScienceDirect
Annales d’Endocrinologie 76 (2015) 25–41
Review
Prostate cancer: The main risk and protective factors –
Epigenetic modifications
Le cancer de la prostate: les principaux facteurs de risque et lesfacteurs protecteurs – Les
modifications épigénétiques
Mawussi Adjakly a,b , Marjolaine Ngollo a,b , Aslihan Dagdemir a,b , Gaëlle Judes a,b ,
Amaury Pajon a,b , Seher Karsli-Ceppioglu a,b,c , Frédérique Penault-Llorca b,d , Jean-Paul Boiteux e ,
Yves-Jean Bignon a,∗,b , Laurent Guy b,e , Dominique Bernard-Gallon a,b
a Département d’oncogénétique, CBRV, centre Jean-Perrin, 28, place Henri-Dunant, BP 38, 63001 Clermont-Ferrand, France
b ERTICA, EA4677, université d’Auvergne, 28, place Henri-Dunant, 63001 Clermont-Ferrand, France
c Département de toxicologie,faculté de pharmacie, université de Marmara, Istanbul, Turkey
d Laboratoire de pathologie médicale, centre Jean-Perrin, 58, rue Montalembert, 63000 Clermont-Ferrand, France
e Département d’urologie, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France
Abstract
With 13 million new cases worldwide every year, prostate cancer is as a very real public health concern. Prostate cancer is common in over-50s
men and the sixth-leading cause of cancer-related death in men worldwide. Like all cancers, prostate cancer is multifactorial – there are non-
modifiable risk factors like heredity, ethnicity and geographic locati
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