Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss a pilot study querying an association beyond coagulation》.pdf

European Journal of Obstetrics Gynecology and Reproductive Biology 185 (2015) 13–18 Contents lists available at ScienceDirect European Journal of Obstetrics Gynecology and Reproductive Biology jou r nal h o mep ag e: w ww .elsevier .co m/loc ate/ejo g rb Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation a,* d d a Sorina Grisaru-Granovsky , Zaidoun Salah , Miriam Maoz , Aharon Tevet MD , Ehud Margalioth b, Arnon Samueloff a, Gheona Altarescu c, Rachel Bar-Shavit d a Division of Maternal Fetal Medicine, Shaare Zedek Medical Center; Jerusalem, Israel b Reproductive Endocrinology and Clinic for Repeated Pregnancy Loss, Shaare Zedek Medical Center; Jerusalem, Israel c Human Genetics Unit, Shaare Zedek Medical Center; Jerusalem, Israel d Department of Oncology and Tumor Biology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel A R T I C L E I N F O A B S T R A C T Article history: Background: Recurrent pregnancy loss (RPL) has been associated with impaired maternal–fetal Received 24 July 2014 communication. Protease-activated-receptor 1 (PAR1) is critical for trophoblast invasion and Accepted 17 November 2014 establishment unrelated to its role in vascular biology. Objectives: To analyze