含吡唑杂环二酰胺类化合物的合成与杀虫活性研究有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 9 期, 1510～1515 Chinese Journal of Organic Chemistry No. 9, 1510～1515 ·研究简报· 含吡唑杂环二酰胺类化合物的合成与杀虫活性研究 葛前建 a 陈列忠 b 杜晓华*,a (a 浙江工业大学催化加氢研究中心 杭州 310014) (b 浙江省农科院 杭州 310021) 摘要 通过活性亚结构拼 , 合成 16 个含吡唑杂环的新型二酰胺类化合物, 其结构通过了 IR, 1H NMR 和 HRMS 的表 征, 其中目标化合物 3h 的结构经X 单晶衍射进一步确认. 初步生测结果表明在 500 mg/L 浓度下, 部分化合物对粘虫和 苜蓿蚜有致死活性; 在 100 mg/L 浓度下部分化合物对茶尺蠖幼虫具有致死活性, 其中毒症状表现为拒食. 关键词 活性亚结构; 双酰胺化合物; 鱼尼汀受体激活剂; 合成; 杀虫活性 Synthesis and Insecticidal Activities of Pyrazole-heterocyclic Diamides Ge, Qianjiana Chen, Liezhongb Du, Xiaohua*,a (a Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014) (b Zhejiang Academy of Agricultural Sciences, Hangzhou 310021) Abstract 16 novel pyrazole-heterocyclic diamides were synthesized according to the principle of combi- 1 nation of bioactive substructures, and their structures were characterized by IR, H NMR and HRMS tech- niques. The crystal structure of 3h was determined by X-ray diffraction analysis. Preliminary bioassays showed that some compounds had lethal activities against Mythimna sepatara and Aphis medicaginis at the dosage of 500 mg/L; some of the compounds had lethal activities against the larvae of Ectropis oblique hy- pulina Wehrli at the dosage of 100 mg/L, the treated insects appeared to have anti-feeding effect.