含吡唑环的1,3,4-噁二唑类衍生物的合成及杀菌活性研究有机化学.pdfVIP

DOI: 10.6023/cjoc201208019 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 含吡唑环的1,3,4-噁二唑类衍生物的合成及杀菌活性研究 孙娜波*,a 童建颖a 武宏科*,b a ( 浙江树人大学生物与环境学院 杭州 310015) (b 浙江工业大学化学工程与材料学院 杭州 310014) 摘要 以乙酰丙酮、水合肼等为原料, 通过多步反应制备了一系列新型含吡唑环的 1,3,4-噁二唑类衍生物, 并考察了微 波辐射对反应的影响. 产物结构均经过 1H NMR, MS 和元素分析确证; 对所有化合物进行了活体杀菌活性测试, 结果 表明大部分化合物对黄瓜褐斑病、黄瓜核菌病、黄瓜霜霉病、黄瓜细菌性角斑病均具有较好的防效. 关键词 1,3,4-噁二唑; 吡唑; 合成; 杀菌活性 Synthesis and Fungicidal Activity of 1,3,4-Oxadiazole Derivatives Containing Pyrazole Moiety Sun, Nabo*,a Tong, Jianyinga Wu, Hongke*,b (a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015) (b College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014) Abstract A series of novel 1,3,4-oxadiazole derivatives were synthesized from acetylacetone, hydrazine hydrate by multi-step reactions. Their structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Corynespora cassiicola, Pseudomonas syringae pv. Lachrymans, Pseudoper- onospora cubensis and Sclerotinia sclerotiorum in vivo, and the results indicated that some of the title compounds displayed excellent fungicidal activities. Keywords 1,3,4-oxadiazole; pyrazole; synthesis; fungicidal activity 杂环化合物是很多天然化合物和合成医药农药中 和 1,3,4-噁二唑以及含 SCH2 官能团合并在同一分子中 的核心结构单元, 因其具有高效低毒及其环上的