四种天然双异戊烯基黄酮的合成及其抑菌活性研究有机化学.pdfVIP

DOI: 10.6023/cjoc201305045 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 四种天然双异戊烯基黄酮的合成及其抑菌活性研究 杨金会* 谢一民 冯尚彪 左武标 陈兵兵 马晓琴 冯 尧 (宁夏大学天然气转化国家重点实验室培育基地 银川 750021) 摘要 Abyssinone-V, 4-hydroxy-6,3,5-triprenylisoflavonone, abyssinone-VI 和 abyssinone-IV 都是从刺桐中分离出来的天 然双异戊烯基黄酮. 利用简单、温和的方法首次完成了这 4 个天然产物的全合成. 初步活性测试表明, 4 个化合物都具 有一定的抑菌活性, 其中, abyssinone-IV 和 abyssinone-V 对金黄葡萄球菌和大肠杆菌都有良好的抑菌效果. 所有新化合 物的结构都经过 HRMS, 1 13 H NMR 和 C NMR 确认. 关键词 异戊烯基黄酮 ; ( ±)-abyssinone-VI; ( ±)-abyssinone-IV; ( ±)-abyssinone-V; 4-hydroxy-6,3,5-triprenyliso- flavonone; 全合成; 抑菌活性 Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids Yang, Jinhui* Xie, Yimin Feng, Shangbiao Zuo, Wubiao Chen, Bingbing Ma, Xiaoqin Feng, Yao (State Key Laboratory Cultivation Base of Natural Gas Conversion, Ningxia University, Yinchuan 750021) Abstract Abyssinone-V, 4-hydroxy-6,3,5-triprenylisoflavonone, abyssinone-VI and abyssinone-IV were all isolated from the genus erythrina. This study completed the first total synthesis of four natural prenylated flavanoids by using simple and facile approaches. The result of their in vitro antibacterial tests indicated that all of them displayed moderate bacteriostatic activities. The compounds abyssinone-IV and abyssinone-V showed remarkable antibacterial activities. The structures of all new compounds have been confirmed by HRMS, 1H NMR and 13C NMR spectra. Keywords prenylated flavan