四一(邻氯苯基)卟吩及其金属络合物的核磁共振谱有机化学.pdfVIP

232 1985 华 有机化学 [ 5 ]张国敏、董i吃华、视虹、刘汉悔， 武汉大学学 参考文献 trz (自然科学版)， 1981(2). 43. [ 1 J Soloway , A. H.. Progress ìn Boron C1iemi- [6J 张国敏、袁国正，有机化学， 1982. 409. Jtry , Ed. by Steinberg , H. and McCloskey , A. [ 7 J Gmelins Handbuch der Anorganischen Chemle L. , Vo l. 1, p. 203. Pergamon press. , Oxford.. Bωtd 48 , Borverbindungen Teil 16 , p. 130. 1964. Springer-Verlag. Berlin. 1977. [2 J Soloway , A. H.; Hatanaka , H. and Davis , M. [ 8 ] a. ibid. , p. 158. A. , 1. Med. Chem.. 1967, 10. 714. b. Povlock , T. P. and Lippincott. W. T. , J.Am. [3J 董世华、张国敏、达世禄、刘家俊、张仕林， Chem. Soc. , 1958, 80 , 5409. 科学通报， 1966. 口. 4J.1. [ 9 J llIesIJ;osa , O. H.; IOpKesH哩， A. M. , JKOX , [4J 盖世华、张国敏、达世禄、刘家饶、张仕林， ì976 , 46 , 348. 武汉大学学报〈自然科学版)， 1979(2).44. STUDIES ON ANTITUMOR BORON COMPOUNDS N • SYNTHESIS AND ANTITUMOR ACTIVITIES OF DIARYLßORINICα-AMINO A ClD ANHYDRIDES Lin Kai Zhang Guomin (Department 01 Chemistry, Wuhan lfníversiry) Fu Naiwu (Cancer hl$titute, Chinese Academy 01 Medical Sciences, Beijing) Ab~ttact: Nineteen new boron compounds have been prepared by reaction of diaryl- borinic acid with various α-amino acids. and their antitumor effects were investigated. Preliminary results showed that the inhibitory ef(ec~s on EAC(mice) of compounds 5(d) and 6(d) were 36.4 % and 49.5% respectively. These compounds were identified by ele-