固-液相转移催化α-芳磺酰基乙酸酯二烷基化有机化学.pdfVIP

有fJL f巳学 YOUJI HUAXUE 1990 , 10, :.li~222 研究论文 - 、 固-j事相转;移催化:α丁-芳磺瞰基Z酸E旨二版基化、? 1 、 j 4J IJ - 1 正、..j，j、玉萍川、 刘广鉴*、张 五_Iii:已川、 ?i~ -f;;-- ，斗 ( ，.;J 川 l 、i ;;: ~;(， 21.0003) A Føcile , Dialkylat;op: of uTAryJsulfoilylacetates under Solid-Liquid Phase Transfer Conditions ;气 LIU Guang-Jiar户， ZHANG Zhen , StJN Yu-Ping*~~~ WANe Yu-Liang* 坪， CAI Song-Chuan (Department of Chemistry, Nal1jillg University, 210008 Nallíing Jiallgs11) Abstract: Tbis ‘ papcr reports a re~arl，ably mild and convenient p1 cthod for the generation of α-arylsulfonylcarbaniop. s and the dialkylations. Thus， α-arylsulfonylacetates (1 a-d) were treated with potassium carbon~t旨 unðf. r solìð-liqúìd phase lniílsler conditions 10 generate the corresponding carbanions and then aHow它d to react iH sítll with aikyl. allylic , and benzylic. C halides according to method 久， B. or C. The alkylation procecdcd very smoothly at 40 C to . give the dialkylated products (2~12) i in good yieJds. Eleven dialkylated compounds w.er~ synthesizcd and fUlly charncterized by;IR. lH NMR , MS , and elCmemtal analysis. The mild reaction conditions , henc巳 the tolerancc of a variety of functional groups, the low moisture sensitivity and easicr manipulation of potassium carbonatë, and thc fI exibility in introducing various alkylàting grbups into the α:posHion of thc substrat~s， accotding to method A , B , or C. make