聚乙二醇干扰素α―2a应用剂量与慢性丙型肝炎抗病毒疗效的关系.docVIP

聚乙二醇干扰素α―2a应用剂量与慢性丙型肝炎抗病毒疗效的关系 【摘要】 目的：探讨聚乙二醇干扰素α-2a（PEG-IFNα-2a）应用剂量与慢性丙型肝炎抗病毒疗效的关系。方法：选取本院慢性丙型肝炎患者67例，采用随机数字表法将患者分为高剂量组32例和低剂量组35例，全部患者均采用PEG-IFNα-2a联合利巴韦林治疗，其中高剂量组采用PEG-IFNα-2a 180 μg/次，低剂量组90 μg/次，1次/周，皮下注射，比较两组抗病毒治疗疗效差异。结果：高剂量组应答率明显高于低剂量组，两组应答率比较差异有统计学意义（P0.05），治疗后，全部患者上述指标均明显低于治疗前，其中高剂量组上述指标明显低于低剂量组，两组比较差异有统计学意义（P 0.05）；但高剂量组不良反应发生率明显高于低剂量组，两组比较差异有统计学意义（P 0.05）。结论：聚乙二醇干扰素α-2a应用剂量与慢性丙型肝炎抗病毒疗效具有明显相关性，其中高剂量PEG-IFNα-2a临床疗效更佳，但增加药物副作用。 【关键词】 聚乙二醇干扰素α-2a； 慢性丙型肝炎； 抗病毒 【Abstract】 Objective：To investigate relationship between the pegylated interferon alpha-2a （PEG-IFN alpha-2a） and the antiviral efficacy of application dose chronic hepatitis C.Method：67 patients with chronic hepatitis C patients in our hospital were selected and randomized divided into high dose group of 32 cases and low dose group of 35 cases，all patients were underwent PEG-IFN alpha-2a combined with Leigh Bhave Lin treatment，high dose group was treated with PEG-IFN alpha -2a 180 μg/time，low dose group 90 μg/time，1 times a week，subcutaneous injection，two groups of antiviral treatment efficacy differences were compared.Result：The response rate of high dose group was significantly higher than that of low dose group，the difference was statistically significant（P0.05），after treatment，all the patients were significantly lower than the index before treatment，the high dose group was significantly lower than that of low dose group，the differences were statistically significant（P 0.05）；but the high dose group of adverse reaction rate was significantly higher than that of low dose group，the difference was statistically significant （P 0.05）.Conclusion：The antiviral efficacy of pegylated interferon alph -2a application dose and chronic hepatitis C was significantly correlated with the high dose，PEG-IFN alpha-2a clinical curative effect is better，but the increase of drug side effects. 【Key words】 Pegylated interferon alpha -2a； Chronic hepatitis C； Antiviral 丙型肝炎病毒（Hepatitis C virus，HCV）是常见的肝炎病毒类型之一，呈全球分布，流行性和传染性较