曲美他嗪联合辛伐他汀治疗不稳定型心绞痛的临床效果分析.docVIP

曲美他嗪联合辛伐他汀治疗不稳定型心绞痛的临床效果分析 　　[摘要] 目的 探讨曲美他嗪联合辛伐他汀治疗不稳定型心绞痛的临床效果。 方法 选择不稳定型心绞痛患者60例为研究对象，将其随机分为联合组和对照组，对照组采用常规治疗，联合组在常规治疗基础上加用曲美他嗪联合辛伐他汀治疗。比较两组的临床疗效。 结果 联合组总有效率为93.3%，对照组为70.0%，两组比较差异有统计学意义（P0.05）。两组治疗后平均每天发作次数显著下降，平均每次发作时间显著缩短，且联合组改善更显著（P0.01）。治疗后联合组血脂、CRP及白细胞计数指标较对照组显著改善（P0.01）。 结论 曲美他嗪联合辛伐他汀治疗不稳定型心绞痛能显著改善疗效，值得临床推广应用。 　　[关键词] 曲美他嗪；辛伐他汀；不稳定型心绞痛 　　[中图分类号] R972+.3 [文献标识码] A [文章编号] 1674-4721（2014）08（a）-0065-03 　　Clinical efficacy of trimetazidine combined with simvastatin in treatment of unstable angina 　　MA Mei-ju 　　The Second Department of Medical，Red Cross Hospital of Puyang City in Henan Province，Puyang 457000，China 　　[Abstract] Objective To discuss the clinical efficacy of trimetazidine combined with simvastatin in treatment of unstable angina. Methods 60 cases of patients with unstable angina for the study were randomly divided into combination group and the control group，control group were received conventional treatment and combination group were treated with trimetazidine combined with simvastatin on the basis of conventional therapy.Clinical efficacy was compared. Results The overall result of the combination group was 93.3% and 70.0% in the control group，the difference between two groups was significant （P0.05）.The number of times per day of two groups before and after treatment significantly decreased，and average onset time was significantly shorter，but the more significant improvement in the combination group （P0.01）.After treatment，the lipids，CRP and WBC of combination group improved more than that of the control group （P0.01）. Conclusion Trimetazidine combined with simvastatin for unstable angina can significantly improve the efficacy，is worthy of promotion. 　　[Key words] Trimetazidine；Simvastatin；Unstable angina 　　不稳定型心绞痛是介于劳累性稳定型心绞痛与急性心肌梗死和猝死之间的临床表现，如果不能恰当及时地治疗，患者可能发展为急性心肌梗死。曲美他嗪为作用较强的抗心绞痛药，其起效较硝酸甘油慢，但作用持续时间较长[1]。辛伐他汀是他汀类的降血脂药物，用于控制血液中胆固醇的含量及预防心血管疾病[2]。本研究在常规治疗的基础上，加用曲美他嗪和辛伐他汀对不稳定型心绞痛进行治疗。 　　1 资料与方法 　　1.1 一般资料 　　选择2013年1～6月在本院治疗的不稳定型心绞痛