Drug target in new drug research and development role.docVIP

 PAGE \* MERGEFORMAT 14 Drug target in new drug research and development role [Abstract] drug target is present in the tissue within the drug-drug interactions, and given the specific molecular effects of drugs, the vast majority of proteins, including a variety of receptors, enzymes. In recent years, with in-depth study of molecular biology, especially the human genome and proteomics research, drug target has become an important means of developing new drugs. This paper reviews the discovery of drug targets, based on targeting drugs in new drug research design and its application prospects. [Keywords:] drug target drug design targeted therapy The so-called drug target (drug target) refers to the cells and drug-drug interactions, and given the specific molecular effects of drugs. More than 98% of drug targets are proteins. Almost 50% of which belong to G protein-coupled receptors (GPCRs), serine, threonine and tyrosine protein kinase, zinc metal peptidase, serine proteases, nuclear hormone receptors, as well as phosphodiesterase other six families. In theory, as the drug targets the protein must be able to in an appropriate combination of chemical characteristics and affinity small molecule compounds, and with the disease. Specifically, as the drug targets the protein to be expressed in pathological cells or tissues, and in cell culture systems can be generated by regulating the activity of target-specific effects, the last of these effects must be reproduced in animal models. In the end, prove an effective drug in the human body after the drug targets can really confirm the value of [1]. Found a role as long as the drug target molecule can be characterized according to their development and design of drugs, as well as targeted therapy. In recent years, the emergence of a large number of molecular biology techniques, particularly in genomics, bioinformatics, proteomics, mass spectrometry and biological macromolecules Interaction Analysis (BIA) such as drivin