Drug treatment of depression randomized double-blind trial balance of Empirical Research on the baseline.docVIP

 PAGE \* MERGEFORMAT 10 Drug treatment of depression randomized double-blind trial balance of Empirical Research on the baseline Author: Yan Yan Hua Lin Zhang belt Rong Fu Ying 【Abstract】 Objective: To understand the drug treatment of depression, double-blind randomized controlled clinical trials, two groups of baseline indicators of the balance. Methods: “China Hospital Digital Library,” Journal of CNKI full text database searching literature, describe the difference between two groups the distribution of baseline indicators, line sign test, and Meta analysis to determine the difference statistically significant. Results: In 82 selected trials, two groups the number of cases, age, sex ratio and duration of disease more balanced view of the differences in the distribution, while the value of the distribution of NAMD seems uneven. Sign test, and qualitative analysis of Ridit tests showed that the test group is greater than the value of HAMD-based study of the control group than the control group is greater than the number of test group the number of differences between two groups statistically significant differences in the distribution. Meta analysis of quantitative analysis showed that the test group than the control value of HAMD-based group Big 0.10,95% CI 0.047 ~ 0.153. Conclusion: The trial group and the control group there is the value of the HAMD-based imbalances; randomized double-blind clinical trials there may also be uneven baseline situation. 【Key Words】 bias in the baseline depression of baseline information, double-blind trial randomized controlled trial Meta-analysis of empirical evidence-based medicine In the randomized controlled double-blind clinical trial, baseline irregularity may be caused by one of the reasons bias test results. Of a randomized double-blind clinical trial in the test group and control group baseline indicator values (pre-intervention in critical condition severity, demographic and other prognos