External treatment of experimental osteoarthritis in rabbit knee synovial membrane in the expression of bFGF.docVIP

 PAGE \* MERGEFORMAT 15 External treatment of experimental osteoarthritis in rabbit knee synovial membrane in the expression of bFGF Abstract: Objective: To understand the external treatment of the basic fibroblast growth factor (bFGF) in experimental osteoarthritis in rabbit knee synovial membrane in the expression and distribution of the effects of traditional Chinese medicine treatment of osteoarthritis External Mechanism . Methods: 32 rats were randomly divided into normal group, model group, Voltaren group and external treatment group, using the femoral vein ligation method of modeling is successful, the treatment for 1 month. By immunohistochemical SABC method of knee joint synovial membrane in experimental animals to observe the distribution of bFGF expression. Results: The model group 24 animals in the knee synovial bFGF immunohistochemistry positive rate was 92% (22/24), and External Group expressed stronger Voltaren group and model group. Normal group, 8 animals in the knee synovium into negative by immunohistochemistry. Conclusion: The external treatment of laboratory animals can promote the expression of bFGF knee synovial membrane, so as to External treatment of osteoarthritis in the levels of cytokines provide a theoretical basis. Keywords:: osteoarthritis; External; basic fibroblast growth factor; synovial Osteoarthritis (osteoarthritis, OA) is a chronic joint disease, also known as degenerative joint disease, proliferative diseases such as joints. Articular cartilage is characterized by occurrence of primary or secondary degeneration, and osteophyte formation in the joint edges. The pathological changes of this disease in order to articular cartilage degeneration and subchondral bone lesions mainly. Traditional Chinese Medicine External Treatment of OA has significant therapeutic effect [1-2]. Basic fibroblast growth factor (bFGF) can induce the ectodermal and mesodermal origin cell proliferation and differentiation, with a