Fluvastatin in patients with acute coronary syndromes of vascular endothelial function in.docVIP

 PAGE \* MERGEFORMAT 4 Fluvastatin in patients with acute coronary syndromes of vascular endothelial function in [Keywords:] Coronary Syndrome [Keywords:] coronary syndrome; vascular endothelial function; fluvastatin 0 Introduction Vascular endothelial dysfunction is not only the early atherosclerotic manifestations, but also may be involved in the pathogenesis of acute coronary syndrome [1]. Studies have shown that lipid-lowering statin drugs to lower cholesterol in the rapidly (CH) can be reduced while the level of the occurrence of cardiovascular events with coronary heart disease and its mechanism may be related to improved endothelial function in the [2]. We have examined the lipid effects of fluvastatin on acute coronary syndrome and endothelial function in patients studied. An object and method 1.1 Object randomly selected our hospital with acute coronary syndrome patients 96 (male 50, female 46) with a mean age (56 ± 17) years of age. Based on the performance of this group of patients were angina pectoris short-term nature, pain, time, degree , and by the electrocardiogram and creatine kinase (CK), creatine kinase isoenzyme (CKMB) Enzymatic diagnosis of unstable angina (UA) or acute myocardial infarction (AMI). to exclude serious heart, liver, kidney dysfunction and cerebral vascular and endocrine diseases, and within 2 wk were not taking lipid-lowering drugs too. 1.2 Methods of cases were randomly selected, single-blind divided into: ① fluvastatin group: 48 cases, UA or non-Q-wave myocardial infarction in 36 cases, there are Q-wave myocardial infarction in 12 cases. ② conventional treatment group: 48 cases, UA or non-Q-wave myocardial infarction in 35 cases, there are Q-wave myocardial infarction in 13 cases. two groups of age, sex, the proportion of smokers, the proportion of high blood pressure and diabetes, blood pressure, heart rate, CPK was no significant difference in the peak. fluvastatin group of conventional treatment, including thro