Fluvastatin on the blood of patients with dilated cardiomyopathy inflammatory mediators and cardiac function in.docVIP

 PAGE \* MERGEFORMAT 10 Fluvastatin on the blood of patients with dilated cardiomyopathy inflammatory mediators and cardiac function in [Keywords:] fluvastatin on inflammatory mediators in patients with dilated cardiomyopathy cardiac function Heart failure is a cardiovascular remodeling and neuro-endocrine system activation as the main manifestations of the clinical syndrome [1]. There is evidence that statins to improve cardiac cell function, cytokine antagonists, anti-inflammatory and other non-lipid effects [2,3]. The study on the basis of conventional therapy plus atorvastatin entrusted with the fluoride to interfere with dilated cardiomyopathy and to determine the changes in serum cytokines, to explore the statin drugs used in non-ischemic cardiomyopathy treatment of the feasibility and possible mechanism. Are reported below. 1 Data and methods 1.1 General Information Select from September 2005 to February 2008 during the Sir Run Run Shaw Hospital, Zhejiang University School of Medicine New-patient treatment of idiopathic dilated cardiomyopathy in 65 cases, 39 cases were male, female 26 cases, the United States New York Heart Society (New York Heart Association, NYHA) grade II ~ III level, including 26 cases of grade Ⅱ , Ⅲ grade 39 cases. Course of the disease were amp;quot;6 months, all cases were characterized by coronary angiography to exclude ischemic heart disease, and to exclude valvular heart disease, diabetes, hypertension, severe liver dysfunction (elevated liver enzymes two times), acute and chronic infection, pregnancy, rheumatic diseases, cancer, heart function IV class, are taking or have taken within 3 months before statins or fibrates and other lipid-lowering drugs cases. Were randomly divided into fluvastatin group (n = 33 cases) and control group (n = 32 cases), treatment for 6 months. 1 case each in both groups died during the follow-up, including the control group had 1 case lost to follow, so the actual completion of the control gr