Fluvastatin on LPS and angiotensinaortic endothelial cells induced the expression of TF and TFPI.docVIP

 PAGE \* MERGEFORMAT 19 Fluvastatin on LPS and angiotensinaortic endothelial cells induced the expression of TF and TFPI Study: Chun Xiang Xu Qingbin satisfied Ru Zhou Zheng Ping Wang Rui [Abstract] Objective fluvastatin (fluvastatin) on lipopolysaccharide (LPS) and angiotensin (Ang )-induced rat aortic endothelial cells (RAEC) expression of tissue factor (TF) and tissue factor pathway inhibitor (TFPI). Methods cultured RAEC, were treated with LPS and Ang stimulated by ELISA assay of fluvastatin on RAEC TF and TFPI expression. Results Fluvastatin 0.01,0.1,1 and 10 mol / L group could and dose-dependent inhibition of LPS induced TF expression of Ang increased fluvastatin 0.01,0.1,1 and 10 mol / L group increased expression of TFPI in a dose dependent manner. Conclusion Fluvastatin inhibits TF expression induced thrombosis, increased TFPI expression. [Keywords:] Fluvastatin antithrombotic TF TFPI Fluvastatin is the first totally synthetic hydrophilic by hydroxymethyl coenzyme (HMG-COA) reductase inhibitor, in addition to the lipid has a good role, but also with the prevention of cardiovascular diseases, anti-inflammatory antioxidant , immune suppression, and other pharmacological effects [1]. clinically for the treatment of high cholesterol, diseases such as acute coronary syndrome. In recent years the study found that in vivo coagulation activity and pathological process of thrombosis is the key to tissue factor (TF) way to start. TF or coagulation factor , at the start of exogenous and endogenous coagulation play an important role in both. a variety of physiological or pathological stimuli such as lipopolysaccharide (LPS) [2], angiotensin factor (Ang ) [3], etc., can affect endothelial cells in vitro expression of TF, TF can increase the expression of endothelial cells. Thus, under pathological conditions abnormal blood vessels in TF expression and release can quickly start the process of blood coagulation, with a variety of cardiovascular dise