Nitidine chloride in vivo anti-tumor effect and mechanism of.docVIP

 PAGE \* MERGEFORMAT 13 Nitidine chloride in vivo anti-tumor effect and mechanism of [Abstract] Objective To study the chloride nitidine S180 tumor-bearing mice on the anti-tumor effect and its mechanism. Approach to solid tumor tumor-bearing mice as experimental indicators to assess tumor weight nitidine chloride on transplanted sarcoma S180 inhibition, immunohistochemistry to detect tumor tissue p53, Bcl-2 and Bax proteins. Results nitidine chloride 2.5,5 and 10 mg * kg-1 doses on S180 sarcoma growth inhibition rates were 1.95%, 27.3% and 42.9%, p53, bcl-2 protein expression was significantly lower than the control group, bax protein expression rate was higher. Conclusion nitidine chloride inhibition of mouse S180 sarcoma and its mechanism may affect the expression of oncogenes. [Keywords:] nitidum nitidine chloride anti-tumor medicine Abstract: ObjectiveTo investigate the anti-tumor effect of Nitidine chloride in vivo on Sarcoma180 (Sl80) mice and its mechanism. MethodsThe antitumor effect of Nitidine chloride was evaluated by tumor weight. The expressions of p53, bcl-2 and bax proteins in the tissue were studied by immunohistochemistry. ResultsNitidine chloride significantly inhibited the growth of tumor, the inhibitory rate at the dose of 2.5,5,10 mg * kg-1 was 1.95%, 27.3% and 42.9% respectively. The expression of p53, bcl-2 proteins was decreased obviously in the Nitidine chloride group as compared to control group, and the expression of bax was increased. ConclusionNitidine chloride has significant antitumor effect in vivo, and its influence on oncogene may be one of its anti-tumor mechanism. Keywords:: Zanthoxylum nitidum (Roxb.) DC; Nitidine chloride; Anti-tumor; Traditional Chinese medicine Nitidine chloride (Nitidine Chloride) is endemic medicinal plants in Guangxi Zanthoxylum nitidum Zanthoxylum nitidum (Roxb) DC isolated from the root of anti-tumor activity of the alkaloid has, according to [1] reported that right LEWIS lung cancer, the hum