Progress in anti-diabetic effects of Gynostemma.docVIP

 PAGE \* MERGEFORMAT 18 Progress in anti-diabetic effects of Gynostemma [Keywords:] Summary of Gynostemma Diabetes Gynostemma [Gynostemma pentaphyllum (Thunb) Makino], also known as Aescin lamps, as Cucurbitaceae pentaphyllum is a perennial herbaceous vine. Gynostemma effective composition is gypenosides (Gypenosides, GP), has been isolated and identified from Gynostemma 80 A similar variety and ginsenosides dammarane skeleton type gypenosides. studies have shown that Jiaogulan can inhibit tumor, prevent aging, lower blood lipids, enhance immunity, prevention and treatment of glucocorticoid side effects, protect the heart and liver, ulcer pain and sedation other pharmacological effects. The water extract had no significant side effects [1]. In recent years, there have been studies have shown that Jiaogulan and its compound preparations have some blood sugar, improving the role of complications of diabetes, its mechanism of action is becoming more depth. The author is the nearest few years about the role of anti-diabetic Gynostemma and related mechanisms Research summarized below. A hypoglycemic Stimulated insulin release 1.1 Norberg et al [2] in vitro and animal studies have found that islet cells can stimulate gypenosides the release of insulin, a dose dependent manner. They purified from Gynostemma isolated a new saponin, named phanoside, it is Dharma alkane structure, there are 4 kinds can be transformed into each other stereoisomer, can be stimulated rat pancreatic islet cells release insulin. in vitro experiments, normal male Wistar rats were isolated islets, the RPMI1640 culture medium after 24 h in vitro, each group to join the containing 3.3 mmol / L concentration of glucose in the Krebs-Ringer bicarbonate buffer at 37 ℃ for 30 min, then were added to glucose concentration 3.3 mmol / L or 16.7 mmol / L in Krebs-Ringer bicarbonate buffer (treatment group with different concentrations of ethanol extract of Gynostemma or purification of com