Research MTHFR gene associated with schizophrenia Δ.docVIP

 PAGE \* MERGEFORMAT 17 Research MTHFR gene associated with schizophrenia Δ Keywords:] Schizophrenia; methylenetetrahydrofolate reductase; gene research [Keywords:] Schizophrenia; methylenetetrahydrofolate reductase; gene research Since 1961, Pollin W, etc. [1] in the journal Science reported in patients with schizophrenia oral loading dose of methionine (Met) after the symptoms worsen, after testing found that plasma homocysteine (Hcy) levels increased; A recent study found that Asian Base tetrahydrofolate reductase (MTHFR) C677T gene mutation to alanine (Ala) by valine (Val) to replace, resulting in heat resistance and activity of the enzyme decreased elevated levels of plasma Hcy, while high Hcy hyperlipidemia and heart, cerebrovascular diseases, neuropsychiatric diseases, such as the pathogenesis. In this paper, MTHFR gene polymorphism and Hcy and schizophrenia are summarized below. 1 MTHFR with a carbon unit metabolism 1.1 folic acid and Met are a variety of enzymes in the folic acid cycle of the most active group - Coenzyme an important member of the family, which participated in virtually all of the biochemical metabolic processes of life. A typical one-carbon unit transfer process is running body Met in the adenosine triphosphate (ATP) under the action becomes active Met, active Met offers a one-carbon unit of methyl, the formation of Hcy. The latter again with the 5-methyl tetrahydrofolate methyl-carbon units in a synthesis of Met, so that 5-methyl tetrahydrofolate into tetrahydrofolate. Tetrahydrofolate and other biochemical metabolic processes and then generate one-carbon unit of methyl-binding, re-form a 5-methyl tetrahydrofolate. Hcy is an intermediate product of methionine metabolism, in vivo metabolic pathway of Hcy there are two: (1) Hcy in the cystathionine synthase (CBS) and cystathionine catalyzed by the enzyme generates cystine, take vitamins (Vit) B6 participation. (2) Hcy in folate and VitB12 re-methylation of the support of re-syn