Salvia for continuing epilepsy after brain injury in rats Experimental Study on Effects of serum NSE.docVIP

 PAGE \* MERGEFORMAT 16 Salvia for continuing epilepsy after brain injury in rats Experimental Study on Effects of serum NSE 【Key Words】 Salvia;,, convulsions brain injury;,, neuron-specific enolase Abstract: Objective To investigate the Salvia to sustained neuronal injury in young rats with epilepsy may have a protective effect and its mechanism. Methods megimide health of young rats induced by status epilepticus seizures. After randomization executed in batches. Electron microscope ultrastructural changes in hippocampal neurons, ELISA method for measuring serum NSE (neuron-specific enolase) levels. Results Danshen treatment group rats electron microscope, the ultrastructure of hippocampal neurons lighter lesions and serum NSE concentrations were lower than after the onset of the same point in continuing the epilepsy group. Conclusion Danshen on neuronal injury in young rats with epilepsy continue to have some protective effect; serum neuron-specific enolase and neuronal injury in young rats with epilepsy continue to trend of basically the same, to serve as judge neuronal injury and recovery effective indicators. Keywords: Salvia miltiorrhiza; seizures brain injury; neuron-specific enolase Protective Effect of Salvia miltiorrhiza Bge Against Seizure-induced Brain Injury in Young Rats Abstract: ObjectiveTo evaluate the protective effect and mechanism of Salvia miltiorrhiza Bge (SMB) against seizure-induced cerebral neuron injury of premature rats.MethodsMegimide (20mg/kg) was injected into healthy infant rats (21d) to evoke status epilepticus (SE). The ultrastructure changes of the hippocampus neurons were observed under the electronic microscope.At the same time points, the level of neuron speertic enolale NSE in rat sera was tested with ELISA.ResultsThe hippocampus neurons of SE group rats, the mitochondria volume decreased, the matrix condensed, the ridge obscured or disappeared.Compared with the SE group, there was a significant