The new marine actinomycetes and their secondary metabolites research.docVIP

 PAGE \* MERGEFORMAT 19 The new marine actinomycetes and their secondary metabolites research Author: Wang Chun-Xia Zhu Tianjiao domain GU Qian-Qun Zhu Weiming Lu [Abstract] Because of its unique living environment, marine actinomycetes with complex a unique metabolic pathway, resulting in a number of novel structure and biological activity of a significant secondary metabolites, the active metabolite for the new discovery of antibiotics has provided a wealth of pilot compounds, and some have entered pre-clinical studies. This article briefly describes the past 10 years, isolated from marine samples of the new species of actinomycetes and their secondary metabolites is Research. [Keywords:] marine actinomycetes; metabolites; Salinispora; Verrucosispora; Marinispora ABSTRACT Due to the special living environment, marine-derived actinomycetes possess distinct and complex metabolic capabilities, resulting in wide diversity of their secondary metabolites in chemical structure and biological activity. Among them, many valuable leading compounds were obtained for discovery of new antibiotics, and some had been selected for preclinical study. The research advances in discovery of new actinomycetes and their secondary metabolites were briefly reviewed in this paper. KEY WORDS Marine-derived actinomycetes; Metabolites; Salinispora; Verrucosispora; Marinispora Actinomyces is a kind of high (GC)% of the gram-positive bacteria, intimate relationship with humans. Natural antibiotics have been found in 70% of the actinomycetes from the family [1], such as streptomycin, azithromycin, vancomycin, etc., all have a very wide range of clinical applications for human health has made tremendous contribution. With the widespread use of antibiotics, pathogenic bacteria dramatic increase in drug resistance, the original has been substantially reduced efficacy of antibiotics, new diseases are emerging, which gave antibiotic development has brought enormous challenges, the discov