Umbilical cord blood hematopoietic cell growth factor in vitro expansion of the role of progress of the study.docVIP

 PAGE \* MERGEFORMAT 23 Umbilical cord blood hematopoietic cell growth factor in vitro expansion of the role of progress of the study Keywords: hematopoietic Abstract: The human umbilical cord blood hematopoietic stem / progenitor cell proliferation ability, but a limited number of single copies of umbilical cord blood, there is currently more than umbilical cord blood transplantation for low-weight children. Hematopoietic cell growth factor in facilitating expansion of the role of umbilical cord blood in different combined effects of hematopoietic cell growth factors, it can be purposeful in vitro amplification, so that a single cord blood units are expected to address the high weight, umbilical cord blood transplantation in children and adults there is hematopoietic stem / progenitor cells in the problem of insufficient number for the cord blood is widely used in clinical transplantation to contribute. Keywords: hematopoietic cell growth factor; cord blood; of hematopoietic stem / progenitor cells; vitro expansion of umbilical cord blood stem cell transplantation biology research and clinical transplantation for the treatment in recent years made great progress. Since 1988, France, Gluckman, etc. First of all, after the success of transplantation for treatment of Fanconi anemia from around the world have been carrying out in this regard, the current blood system has been successfully used to treat malignant diseases, malignant solid tumors, genetic diseases and other diseases, but a single copy recoverable amount of umbilical cord blood is limited. Regidor [1] such reports a single cord blood units containing nucleated cells (nucleated cells, NC), and CD34 cells were 1.2 × 109 and 3.1 × 106. Gluckman [2] so that the umbilical cord blood transplantation NC and CD34 cells required the ideal value should be, respectively, 3.7 × 107/kg, and 3 × 105/kg recipient body weight, it is currently used for children. Therefore, in vitro expansion of u