E-cadherin对非小细胞肺癌的转移和靶向治疗的影响.pdfVIP

昆明医科大学学报 2014 ,35( 4) : 164-167 CN 53 -1221/ R Journal of Kunmiog Medical University E-cadherin 对非小细胞肺癌的转移和靶向治疗的影晌 周苗条1)综述阮锐飞边莉虫审校 (1) 昆明医科大学基础医学院病理学教研室，云南昆明 650500 ; 2) 昆明医科大学第一附属医院骨科， 云南昆明 650032; 3) 昆明医科大学第一附属医院病理科，云南昆明 650032) [摘要] E-cadherin 是维持上皮细胞极性和上皮完整性的重要分子，也是细胞上皮表型的主要标志.在肿瘤 发生侵袭和转移的过程中上皮-间质转化 (epithelial-mesenchymal transition , EMT) 起了重要的作用， E-cadherin 蛋白的表达缺失是 EMT 发生的主要标志. E-cadherin 的异常表达对非小细胞肺癌的转移及患者的靶向治疗效果均 有影响，就E-cadl凹m 在非小细胞肺癌的转移和靶向治疗中的作用进行综述. [关键词] E-cadherin; 非小细胞肺癌;转移;分子靶向治疗 [中图分类号] R734.2 [文献标识码] A [文章编号] 2095-6 1OX (2014) 04-0164-04 Impact of E-cadherin on Metastasis and Molecular Targeted Therapy in Non-small Cell Lung Cancer ZHOU Zhe-yan 1), RUAN Rui 刀， BIAN Li 3) (1) Dept. of Pathology , School of Bαsic Medicine Kunming Medical Univers即， Kunming Yunnan 650500; 2) Dept. of Orthopedics; 3) Dept. of Pathology , The 1st Affiliated Hospital of Kunming Medical University , Kunming Yunnan 650032 , Chinα) [Abstract] E-cadherin is a key molecule in maintaining cell polarity and epithelial integerity , and it is the main symbol of epithelial phenotype. The process of epithelial-mesenchymal transition (EMT) plays a critical role in the invasion and metastasis of tumor , while the deletion of E-cadherin protein expression is a defining characteristic of EMT. The abnormal expression of E-cadherin is associated with both metastasis and molecular targeted therapy of patients with non-small celllung cancer. This review summarizes the relation of E-cadherin with metastasis and molecular targeted therapy in non-small celllung cancer. [Key words] E-cadl阳i盯 Carcinoma; Non-small-celllung; Metastasis; Molec