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Cell Therapy in Chagas Disease英文文献资料.doc

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Cell Therapy in Chagas Disease英文文献资料

HindawiPublishingCorporation InterdisciplinaryPerspectivesonInfectiousDiseases Volume2009,ArticleID484358,6pages doi:10.1155/2009/484358 ReviewArticle CellTherapyinChagasDisease AntonioC.CamposdeCarvalho,1,2,3ReginaC.S.Goldenberg, 3 LindaA.Jelicks, andHerbertB.Tanowitz 6 4 MilenaB.P.Soares, 5 RicardoRibeirodosSantos, 5 DavidC.Spray, 2 1 2 3 4 5 6 InstitutoNacionaldeCardiologia,22240-006RiodeJaneiro,RJ,Brazil DominickP.Purpura,DepartmentofNeuroscience,AlbertEinsteinCollegeofMedicine,Bronx,NY10461,USA InstitutodeBiof′?sicaCarlosChagasFilho,UniversidadeFederaldoRiodeJaneiro,21941-590RiodeJaneiro,RJ,Brazil DepartmentofPhysiologyBiophysics,AlbertEinsteinCollegeofMedicine,Bronx,NY10461,USA CentrodePesquisasGonc?aloMoniz,Fundac??aoOswaldoCruz,40296-70Salvador,BA,Brazil DepartmentofPathology,AlbertEinsteinCollegeofMedicine,Bronx,NY10461,USA CorrespondenceshouldbeaddressedtoHerbertB.Tanowitz,tanowitz@ Received5April2009;Accepted11May2009 RecommendedbyLouisM.Weiss ChagasdiseasewhichiscausedbytheparasiteTrypanosomacruziisanimportantcauseofcardiomyopathyinLatinAmerica.In laterstageschagasiccardiomyopathyisassociatedwithcongestiveheartfailurewhichisoftenrefractorytomedicaltherapy.In theseindividualshearttransplantationhasbeenattempted.However,thisprocedureisfraughtwithmanyproblemsattributable tothesurgeryandthepostsurgicaladministrationofimmunosuppressivedrugs.Studiesinmicesuggestthatthetransplantationof bone-marrow-derivedcellsamelioratesthein?ammationand?brosisintheheartassociatedwiththisinfection.Cardiacmagnetic resonanceimagingrevealsthatbonemarrowtransplantationamelioratestheinfectioninducedrightventricularenlargement.On thebasisoftheseanimalstudiesthesafetyofautologousbonemarrowtransplantationhasbeenassessedinpatientswithchagasic end-stageheartdisease.Theinitialresultsareencouragingandmorestudiesneedtobeperformed. Copyright?2009AntonioC.CamposdeCarvalhoetal.ThisisanopenaccessarticledistributedundertheCreativeCommons AttributionLicense,whichpermitsunrestricteduse,distribu