Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode 英文参考文献.docVIP

Sensors 2008, 8, 3952-3969; DOI: 10.3390/s8063952 OPEN ACCESS sensors ISSN 1424-8220 /sensors Article Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode Codru?a Cofan 1,* and Ciprian Radovan 2 1 University of Medicine and Pharmacy “Victor Babe?” Timi?oara, Pia?a E. Murgu, Nr. 2, 300041 Timi?oara, Romania 2 West University of Timi?oara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timi?oara, Romania; E-mail: radovan@cbg.uvt.ro (C.R.) * Author to whom correspondence should be addressed; E-Mail: cofancodruta@umft.ro (C. C.); Tel. + 40-256 49 46 04; Fax + 40-256 49 46 04 Received: 21 May 2008; in revised form: 9 June 2008 / Accepted: 9 June 2008 / Published: 12 June 2008 Abstract: Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application