Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response 英文参考文献.docVIP

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Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response 英文参考文献.doc

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Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response 英文参考文献

SomaticPairingofChromosome19inRenalOncocytoma IsAssociatedwithDeregulatedELGN2-Mediated Oxygen-SensingResponse JulieM.Koeman1.,RyanC.Russell2.,Min-HanTan3,4,5,6.,DavidPetillo3,MichaelWestphal3 ,Katherine Koelzer1,JulieL.Metcalf2,ZhongfaZhang3,DaisukeMatsuda3,KarlJ.Dykema7,HeatherL.Houseman7, EricJ.Kort8,LauraL.Furge3,RichardJ.Kahnoski9,Ste′phaneRichard10,11,12,AnnickVieillefond12,13 , PamelaJ.Swiatek1,BinTeanTeh3,4,MichaelOhh2,KyleA.Furge7* 1LaboratoryofGermlineModificationandCytogenetics,VanAndelResearchInstitute,GrandRapids,Michigan,UnitedStatesofAmerica,2DepartmentofLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, 3Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan, UnitedStatesofAmerica,4NCCS-VARITranslationalResearchLaboratory,NationalCancerCentreofSingapore,Singapore,Singapore,5DepartmentofMedicalOncology, NationalCancerCenterofSingapore,Singapore,Singapore,6CentreforMolecularEpidemiology,DepartmentofCommunity,OccupationalandFamilyMedicine,National UniversityofSingapore,Singapore,Singapore,7LaboratoryofComputationalBiology,VanAndelResearchInstitute,GrandRapids,Michigan,UnitedStatesofAmerica, 8Laboratory ofMolecular Epidemiology,Van Andel Research Institute, Grand Rapids, Michigan,United States ofAmerica, 9Department ofUrology, SpectrumHealth Hospital,GrandRapids,Michigan,UnitedStatesofAmerica,10Ge′ne′tiqueOncologiqueEPHE,FrenchKidneyCancerConsortium,AP-HP,Serviced’Urologie,LeKremlin- Bice?tre,France,11CNRSFRE2939,InstitutGustaveRoussy,Villejuif,France,12FrenchKidneyCancerConsortium,Paris,France,13Laboratoired’AnatomiePathologique, AP-HP,Ho?pitalCochin,Paris,France Abstract Chromosomalabnormalities,suchasstructuralandnumericalabnormalities,areacommonoccurrenceincancer.Theclose association of homologous chromosomes during interphase, a phenomenon termed somatic chromosome pairing, has been observed in cancerous cells, but the functional consequences of somatic pairing have not been establis