Somatic comorbidity in anorexia nervosa First results of a 21-year follow-up study on female inpatients 英文参考文献.docVIP
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Somatic comorbidity in anorexia nervosa First results of a 21-year follow-up study on female inpatients 英文参考文献
Erduretal.BioPsychoSocialMedicine2012,6:4
/content/6/1/4
RESEARCH
OpenAccess
Somaticcomorbidityinanorexianervosa:First
resultsofa21-yearfollow-upstudyonfemale
inpatients
LaurenceErdur1*,BettinaKallenbach-Dermutz1,VickyLehmann2,FrankZimmermann-Viehoff1,WernerK?pp1,
CoraWeber1andHans-ChristianDeter1
Abstract
Background:Anorexianervosaisaseverepsychosomaticdiseasewithsomaticcomplicationsinthelong-term
courseandahighmortalityrate.Somaticcomorbiditiesindependentofanorexianervosahaverarelybeenstudied,
butposeachallengetoclinicalpractitioners.Weinvestigatedsomaticcomorbiditiesinaninpatientcohortand
comparedsomaticallyillanorexicpatientsandpatientswithoutasomaticcomorbidity.Inordertoevaluatethe
impactofsomaticcomorbidityforthelong-termcourseofanorexianervosa,wemonitoredsurvivalinalong-term
follow-up.
Method:Onehundredandsixty-ninefemaleinpatientswithanorexianervosaweretreatedattheCharité
UniversityMedicalCentre,CampusBenjaminFranklin,Berlin,between1979and2011.Weconductedretrospective
analysesusingpatient’smedicalandpsychologicalrecords.Informationonsurvivalandmortalitywererequired
throughthelocalregistrationofficeandwasavailableforonehundredpatients.Themeanfollow-upintervalfor
thissubgroupwasm=20.9years(sd=4.7,min=13.3,max=31.6,range=18.3).Weconductedsurvivalanalysis
usingcoxregressionandincludedsomaticcomorbidityinamultivariatemodel.
Results:N=41patients(24.3%)showedasomaticcomorbidity,n=13patients(7.7%)showedsomatic
comorbiditiesrelatedtoanorexianervosaandn=26patients(15.4%)showedsomaticcomorbiditiesindependent
ofanorexianervosa,n=2patientsshowedsomaticcomplicationsrelatedtootherpsychiatricdisorders.Patients
withasomaticcomorbidityweresignificantlyolder(m=29.5,sd=10.3vsm=25.0,sd=8.7;p=.006),showeda
lateranorexianervosaonset(m=24.8,sd=9.9vs.m=18.6,sd=5.1;p.000)andalongerdurationof
treatmentinourclinic(m=66.6,sd=50.3vs.m=50.0,sd=47;p=.05)thaninpatientswithoutsomatic
comorbidity.Outof100patients,9patients(9%)haddied,onaverageatageofm=37years(sd=9.5).Mortality
wasmorecommon
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