Somatic comorbidity in anorexia nervosa First results of a 21-year follow-up study on female inpatients 英文参考文献.docVIP

Somatic comorbidity in anorexia nervosa First results of a 21-year follow-up study on female inpatients 英文参考文献.doc

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Somatic comorbidity in anorexia nervosa First results of a 21-year follow-up study on female inpatients 英文参考文献

Erduretal.BioPsychoSocialMedicine2012,6:4 /content/6/1/4 RESEARCH OpenAccess Somaticcomorbidityinanorexianervosa:First resultsofa21-yearfollow-upstudyonfemale inpatients LaurenceErdur1*,BettinaKallenbach-Dermutz1,VickyLehmann2,FrankZimmermann-Viehoff1,WernerK?pp1, CoraWeber1andHans-ChristianDeter1 Abstract Background:Anorexianervosaisaseverepsychosomaticdiseasewithsomaticcomplicationsinthelong-term courseandahighmortalityrate.Somaticcomorbiditiesindependentofanorexianervosahaverarelybeenstudied, butposeachallengetoclinicalpractitioners.Weinvestigatedsomaticcomorbiditiesinaninpatientcohortand comparedsomaticallyillanorexicpatientsandpatientswithoutasomaticcomorbidity.Inordertoevaluatethe impactofsomaticcomorbidityforthelong-termcourseofanorexianervosa,wemonitoredsurvivalinalong-term follow-up. Method:Onehundredandsixty-ninefemaleinpatientswithanorexianervosaweretreatedattheCharité UniversityMedicalCentre,CampusBenjaminFranklin,Berlin,between1979and2011.Weconductedretrospective analysesusingpatient’smedicalandpsychologicalrecords.Informationonsurvivalandmortalitywererequired throughthelocalregistrationofficeandwasavailableforonehundredpatients.Themeanfollow-upintervalfor thissubgroupwasm=20.9years(sd=4.7,min=13.3,max=31.6,range=18.3).Weconductedsurvivalanalysis usingcoxregressionandincludedsomaticcomorbidityinamultivariatemodel. Results:N=41patients(24.3%)showedasomaticcomorbidity,n=13patients(7.7%)showedsomatic comorbiditiesrelatedtoanorexianervosaandn=26patients(15.4%)showedsomaticcomorbiditiesindependent ofanorexianervosa,n=2patientsshowedsomaticcomplicationsrelatedtootherpsychiatricdisorders.Patients withasomaticcomorbidityweresignificantlyolder(m=29.5,sd=10.3vsm=25.0,sd=8.7;p=.006),showeda lateranorexianervosaonset(m=24.8,sd=9.9vs.m=18.6,sd=5.1;p.000)andalongerdurationof treatmentinourclinic(m=66.6,sd=50.3vs.m=50.0,sd=47;p=.05)thaninpatientswithoutsomatic comorbidity.Outof100patients,9patients(9%)haddied,onaverageatageofm=37years(sd=9.5).Mortality wasmorecommon

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