Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana 英文参考文献.docVIP

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Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana 英文参考文献.doc

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Open Access Me d 2004WilleetVoalu.metho5, Issue 11, Article R92 Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana Anja Wille*??, Philip Zimmermann*§, Eva Vranová*§, Andreas Fürholz*§, Oliver Laule*§, Stefan Bleuler*?, Lars Hennig*§, Amela Preli?*?, Peter von Rohr*￥, Lothar Thiele*?, Eckart Zitzler*?, Wilhelm Gruissem*§ and Peter Bühlmann*? Addresses: *Reverse Engineering Group, Swiss Federal Institute of Technology (ETH), Zurich. ?Colab, ETH, Zurich 8092, Switzerland. ?Seminar for Statistics, ETH, Zurich 8092, Switzerland. §Institute for Plant Sciences and Functional Genomics Center Zurich, ETH, Zurich 8092, Switzerland. ?Computer Engineering and Networks Laboratory, ETH, Zurich 8092. ￥Institute of Computational Science, ETH, Zurich 8092, Switzerland. Correspondence: Anja Wille. E-mail: awille@inf.ethz.ch. Philip Zimmermann. E-mail: philip.zimmermann@ipw.biol.ethz.ch Published: 25 October 2004 Genome Biology 2004, 5:R92 Received: 12 May 2004 Revised: 21 July 2004 Accepted: 27 August 2004 The electronic version of this article is the complete one and can be found online at /2004/5/11/R92 ? 2004 Wille et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SparseispoprAengraphicaloivdelbaiopspyrnoGaussiantahcehsifsorpamtmodelinghodwealylinngAgoferanthebei-dreoisoprenoidgpusilsato/rpynegenetwornetworkks, basedinonArabidopsisgraphical Gthalianaaussian modelling, is used to create a network for the Abstract We present a novel graphical Gaussian modeling approach for reverse engineering of genetic regulatory networks with many genes and few observations. When applying our approach to infer a gene network for isoprenoid biosynthesis in Arabidopsis thaliana, we detect modules