重庆地区脊柱结核耐药情况流行病学调查初步报告.pdfVIP

1420 重庆医学 2010 年 6 月第 39 卷第 11 期 ·调查报告· 重庆地区脊柱结核耐药情况流行病学调查初步报告 吴铮，张泽华，许建中A (第三军医大学西南医院骨科，重庆 400038) 摘 要:目的 了解重庆地区脊柱结核耐药的流行现状。方法 选择本科手术治疗的脊柱结核患者 135 例，对病灶腺泼、千 画各样坏死组织进行 BACT/ ALERT 3D 系统快速培养，培养阳性者再采用改良罗氏培养基按绝对浓度法进行药敏试验，已有药教 结果显示的 119 例纳入本组。结果 119 例标本培养阳性率为 43.7%(52/11的。耐药率为 16%09/119) ，耐多药率为 4.2%(5/ 119) 。耐药分布于 7 种抗，结核药物，其中耐 1 种药物 11 例，耐 2 种药物 4 例，耐 3 种药物 l 例，耐 4 种药物 l 例，耐 5 种药物 l 例， 耐 6 种药物 I 例。结论 重庆地区脊柱结核耐药的形势严峻，广泛开展药敏试验及流行病学调查，对全面掌握脊柱结核耐药情 况、指导1降床治疗具有重大意义。 关键词:重庆g 脊柱结核z 耐药 z 流行病学调查 中圄分类号:R529. 2;R18 1. 32 文献标识码:A 文章编号: 1671-8348(2010) 11-1420-02 Prelimin剑γepidemiol略ical study of drug-r嘀istant spinal tuberculωis in Chongqing WU Zheng ,Z HA NG Z e-hua ,XU J ian-zhong[). ( Department 0/ Orthopaedics ,Southwest Hosρital ,Third Military Medical Unit肥rsity ,Chongqing 400038 ,China) A恼tract:O均ective To find out the status quo of drug-resistant spinal tuberculosis in Chongqing. Meth崎s 135 patients were diagnosed spinal tuberculosis from August 2005 to February 2010. Their specimens were processed in a routine laboratory proce- dure ,and were inoculated into vials of the BACT/ALERT 3D system. The drug susceptibility testing was performed using absolute concentration method ,which included 4 first-line drugs and 7 second- Iine drugs. 119 cases had the drug susceptibility test results and were analyzed. Results The culture positive rate was 45. 2 % (28/62) ,the drug susceptibility testing showed a total drug resist- ance level of 16% (1 9/11 的，and a total multi-drug resistance level of 4. 2 % (5/119). Drug-resistant distributed in 7 kinds of anti- tuberculosis drugs: 11 cases of resistance to one kind of drug ,4 cases of resistance to t