Ⅲc及Ⅳ期卵巢上皮性癌患者行新辅助化疗及间歇性肿瘤细胞减灭术的预后分析.pdf

论著·临床论坛 CHINESECOMMUNITY DOCTORS Ⅲc及Ⅳ期卵巢上皮性癌患者行新辅助化疗 及间歇性肿瘤细胞减灭术的预后分析 骆岚 杜雪莲 272000山东省济宁市第一人民医院妇科 doi:10.3969/j.issn.1007-614x.2017.5.21 摘 要 目的：分析Ⅲc及Ⅳ期卵巢上皮性癌患者行新辅助化疗及间歇性肿瘤细胞减灭术的预后。方法：研究组给予 新辅助化疗+肿瘤细胞减灭术(NACT组)，对照组给予规范的初次肿瘤细胞减灭术+辅助化疗(无NACT组)，比较两组 患者的预后。结果：NACT组发生术后残留少(P＜0.05)，NACT组再行间歇性肿瘤细胞减灭术概率降低。结论：新辅 助化疗未明显改善Ⅲc及Ⅳ期的卵巢上皮癌患者的预后，NACT组术后残留减少，肿瘤细胞减灭术的满意切除率增 高，再行间歇性肿瘤细胞减灭术的概率降低，从而有利于患者改善生活质量。 关键词 新辅助化疗；Ⅲc及Ⅳ期卵巢上皮性癌；间歇性肿瘤细胞减灭术；预后 Analysisoftheprognosisofneoadjuvantchemotherapyandintermittentcytoreductivesurgeryinpatientswithstage Ⅲ candstage Ⅳepithelialovariancancer LuoLan,DuXuelian DepartmentofGynaecology,JiningCityFirstPeoplesHospitalofShandongProvince272000 Abstract Objective:Toanalyzetheprognosisofneoadjuvantchemotherapyandintermittentcytoreductivesurgeryinpatients withstage Ⅲcandstage Ⅳ epithelialovariancancer.Methods:Thestudygroupwasgivenneoadjuvantchemotherapyand cytoreductivesurgery(theNACTgroup).Thecontrolgroupwasgiventhestandardprimarycytoreductivesurgeryandadjuvant chemotherapy(thenoNACTgroup).Theprognosisofthetwogroupsofpatientswerecompared.Results:TheNACTgrouphadless postoperativeresidual(P＜0.05).TheprobabilityofintermittentcytoreductivesurgeryagainintheNACTgroupwasreduced. Conclusion:Neoadjuvantchemotherapynotsignificantlyimprovestheprognosisofpatientswithstage Ⅲcandstage Ⅳepithelial ovariancancer;thepostoperativeresidualoftheNACTgroupisreduced;thesatisfactoryresectionrateofcytoreductivesurgeryis increased;theprobabilityofintermittentcytoreductivesurgeryagainisreduced,whichisbeneficialtoimprovethelifequalityof patients. Keywords Neoadjuvantchemotherapy;Stage Ⅲcandstage Ⅳ epithelialovariancancer;Intermittentcytoreductivesurgery; Prognosis 新辅助化疗是指在明确卵巢癌诊断 表1 两组患者临床病理特征比较 后，先行有限疗程化